MolNFT v1 · #104406 · protein
P-glycoprotein at 3.4 a resolution
4Q9H · Multidrug resistance protein 1A: “P-glycoprotein at 3.4 a resolution”. X-ray diffraction, 14 pockets (best druggability 0.78). MolNFT v1 #104406 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4Q9H
- Type
- protein
- Length
- 1,182 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Multidrug resistance protein 1A
- EC
- 3.6.3.44
- UniProt
- P21447
- Pockets
- 14 · best druggability 0.78
Structure
x-ray diffraction · 1 distinct chain · 64% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Multidrug resistance protein 1A (EC 3.6.3.44) | protein | 1182 | 64% helix, 9% strand | P21447 |
Pockets
14 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1156 | 0.78 | 0.79 | 97 | empty |
| 2 | 209 | 0.60 | 0.81 | 26 | empty |
| 3 | 267 | 0.60 | 0.79 | 30 | empty |
| 4 | 212 | 0.56 | 0.79 | 34 | empty |
| 5 | 165 | 0.53 | 0.79 | 28 | empty |
Compared structures
- 4Q9H · P-glycoprotein at 3.4 A resolution · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21447
- Elsewhere: RCSB PDB 4Q9H · PDBe 4Q9H · UniProt P21447
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