MolNFT v1 · #124788 · protein
Mouse pgp methylated protein
5KPJ · Multidrug resistance protein 1A: “Mouse pgp methylated protein”. X-ray diffraction, 16 pockets (best druggability 0.76). MolNFT v1 #124788 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5KPJ
- Type
- protein
- Length
- 1,177 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Multidrug resistance protein 1A
- EC
- 3.6.3.44
- UniProt
- P21447
- Pockets
- 16 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 64% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Multidrug resistance protein 1A (EC 3.6.3.44) | protein | 1177 | 64% helix, 10% strand | P21447 |
Pockets
16 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 844 | 0.76 | 0.79 | 60 | empty |
| 2 | 379 | 0.71 | 0.83 | 46 | empty |
| 3 | 137 | 0.64 | 0.87 | 22 | empty |
| 4 | 172 | 0.62 | 0.83 | 23 | empty |
| 5 | 80 | 0.61 | 0.89 | 22 | empty |
Modifications
Observed in the structure: 2 modified (methylation).
Compared structures
- 5KPJ · Mouse pgp methylated protein · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21447
- Elsewhere: RCSB PDB 5KPJ · PDBe 5KPJ · UniProt P21447
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