MolNFT v1 · #184538 · protein
Structure of ABCB1/P-glycoprotein in the presence of the cftr potentiator ivacaftor
7OTG: “Structure of ABCB1/P-glycoprotein in the presence of the cftr potentiator ivacaftor”. Electron microscopy, 1 ligand (VX7). MolNFT v1 #184538 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7OTG
- Type
- protein
- Length
- 1,179 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P21447
- Ligands
- VX7
Structure
electron microscopy · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 1179 | — | P21447 |
Ligands and binding sites
- VX7 · N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7OTG · Structure of ABCB1/P-glycoprotein in the presence of the CFTR potentiator ivacaftor · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21447
- Elsewhere: RCSB PDB 7OTG · PDBe 7OTG · UniProt P21447
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