UniProt P14900
UDP-N-acetylmuramoylalanine--D-glutamate ligase (P14900)
UDP-N-acetylmuramoylalanine--D-glutamate ligase (UniProt P14900): 42 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 8 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P14900
- Protein
- UDP-N-acetylmuramoylalanine--D-glutamate ligase
- Experimental structures
- 42
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 8 · 2 records with a druggable one
Structures
43 records of P14900 in the MolNFT archive: 42 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1E0D | UDP-N-Acetylmuramoyl-L-Alanine:D-Glutamate Ligase | x-ray diffraction | A | — | — |
| 1E0D | Udp-N-acetylmuramoyl-L-ALANINE:D-glutamate ligase | x-ray diffraction | A | — | — |
| 1EEH | Udp-N-acetylmuramoyl-L-ALANINE:D-glutamate ligase | x-ray diffraction | A | — | — |
| 1EEH | Udp-N-acetylmuramoyl-L-ALANINE:D-glutamate ligase | x-ray diffraction | A | — | — |
| 1UAG | Udp-N-acetylmuramoyl-L-ALANINE:D-glutamate ligase | x-ray diffraction | A | — | — |
| 1UAG | Udp-N-acetylmuramoyl-L-ALANINE:D-glutamate ligase | x-ray diffraction | A | — | — |
| 2JFF | Crystal structure of MurD ligase in complex with D-Glu containing sulfonamide inhibitor | x-ray diffraction | A | — | — |
| 2JFF | Crystal structure of murd ligase in complex with D-glu containing sulfonamide inhibitor | x-ray diffraction | A | — | — |
| 2JFG | Crystal structure of MurD ligase in complex with UMA and ADP | x-ray diffraction | A | — | — |
| 2JFG | Crystal structure of murd ligase in complex with uma and ADP | x-ray diffraction | A | — | — |
| 2JFH | Crystal structure of MurD ligase in complex with L-Glu containing sulfonamide inhibitor | x-ray diffraction | A | — | — |
| 2JFH | Crystal structure of murd ligase in complex with L-glu containing sulfonamide inhibitor | x-ray diffraction | A | — | — |
| 2UAG | Udp-N-acetylmuramoyl-L-ALANINE:D-glutamate ligase | x-ray diffraction | A | — | — |
| 2UAG | Udp-N-acetylmuramoyl-L-ALANINE:D-glutamate ligase | x-ray diffraction | A | — | — |
| 2UUO | Crystal structure of MurD ligase in complex with D-Glu containing sulfonamide inhibitor | x-ray diffraction | A | — | — |
| 2UUO | Crystal structure of murd ligase in complex with D-glu containing sulfonamide inhibitor | x-ray diffraction | A | — | — |
| 2UUP | Crystal structure of MurD ligase in complex with D-Glu containing sulfonamide inhibitor | x-ray diffraction | A | — | — |
| 2UUP | Crystal structure of murd ligase in complex with D-glu containing sulfonamide inhibitor | x-ray diffraction | A | — | — |
| 2VTD | Crystal structure of MurD ligase in complex with D-Glu containing sulfonamide inhibitor | x-ray diffraction | A | — | — |
| 2VTD | Crystal structure of murd ligase in complex with D-glu containing sulfonamide inhibitor | x-ray diffraction | A | — | — |
| 2VTE | Crystal structure of MurD ligase in complex with D-Glu containing sulfonamide inhibitor | x-ray diffraction | A | — | — |
| 2VTE | Crystal structure of murd ligase in complex with D-glu containing sulfonamide inhibitor | x-ray diffraction | A | — | — |
| 2WJP | Crystal structure of murd ligase in complex with D-glu containing rhodanine inhibitor | x-ray diffraction | A | — | — |
| 2WJP | Crystal structure of murd ligase in complex with D-glu containing rhodanine inhibitor | x-ray diffraction | A | — | — |
| 2X5O | Discovery of Novel 5-Benzylidenerhodanine- and 5-Benzylidene- thiazolidine-2,4-dione Inhibitors of… | x-ray diffraction | A | — | — |
| 2X5O | Discovery of novel 5-benzylidenerhodanine- and 5-benzylidene- thiazolidine-2,4-dione inhibitors of… | x-ray diffraction | A | — | — |
| 2Y1O | Dual-target Inhibitor of MurD and MurE Ligases: Design, Synthesis and Binding Mode Studies | x-ray diffraction | A | — | — |
| 2Y1O | Dual-target inhibitor of murd and mure ligases: design, synthesis and binding mode studies | x-ray diffraction | A | — | — |
| 2Y66 | New 5-Benzylidenethiazolidine-4-one Inhibitors of Bacterial MurD Ligase: Design, Synthesis, Crystal… | x-ray diffraction | A | — | — |
| 2Y66 | New 5-benzylidenethiazolidine-4-one inhibitors of bacterial murd ligase: design, synthesis, crystal… | x-ray diffraction | A | — | — |
| 2Y67 | New 5-Benzylidenethiazolidine-4-one Inhibitors of Bacterial MurD Ligase: Design, Synthesis, Crystal… | x-ray diffraction | A | — | — |
| 2Y67 | New 5-benzylidenethiazolidine-4-one inhibitors of bacterial murd ligase: design, synthesis, crystal… | x-ray diffraction | A | — | — |
| 2Y68 | Structure-based design of a new series of D-glutamic acid-based inhibitors of bacterial MurD ligase | x-ray diffraction | A | — | — |
| 2Y68 | Structure-based design of a new series of D-glutamic acid-based inhibitors of bacterial murd ligase | x-ray diffraction | A | — | — |
| 3UAG | Udp-N-acetylmuramoyl-L-ALANINE:D-glutamate ligase | x-ray diffraction | A | — | — |
| 3UAG | Udp-N-acetylmuramoyl-L-ALANINE:D-glutamate ligase | x-ray diffraction | A | — | — |
| 4UAG | Udp-N-acetylmuramoyl-L-ALANINE:D-glutamate ligase | x-ray diffraction | A | — | — |
| 4UAG | Udp-N-acetylmuramoyl-L-ALANINE:D-glutamate ligase | x-ray diffraction | A | — | — |
| 5A5E | Crystal structure of murd ligase from escherichia COLI | x-ray diffraction | A | — | — |
| 5A5E | Crystal structure of murd ligase from escherichia COLI | x-ray diffraction | A | — | — |
| 5A5F | Crystal structure of murd ligase from escherichia COLI in complex with uma and ADP | x-ray diffraction | A | — | — |
| 8V8X | Crystal Structure of Apo UDP-N-acetylmuramoylalanine--D-glutamate ligase (MurD) from E. coli… | x-ray diffraction | A | GLY | 7 (best 0.60) |
| P14900 | AlphaFold monomer V2.0 prediction for udp-N-acetylmuramoylalanine-- D-glutamate ligase (P14900) | predicted | A | — | 1 (best 0.74) |
Ligands
- GLY · Glycine · in 1 record
Experiment against prediction
- 4UAG chain A against the predicted model P14900: TM-score 0.97, RMSD 1.23 Å
- 4UAG chain A against the predicted model P14900: TM-score 0.97, RMSD 1.23 Å
- 2X5O chain A against the predicted model P14900: TM-score 0.97, RMSD 1.29 Å
- 2X5O chain A against the predicted model P14900: TM-score 0.97, RMSD 1.29 Å
- 2Y68 chain A against the predicted model P14900: TM-score 0.97, RMSD 1.20 Å
- 2Y68 chain A against the predicted model P14900: TM-score 0.97, RMSD 1.20 Å
- 2WJP chain A against the predicted model P14900: TM-score 0.97, RMSD 1.26 Å
- 2WJP chain A against the predicted model P14900: TM-score 0.97, RMSD 1.26 Å
- 2Y66 chain A against the predicted model P14900: TM-score 0.96, RMSD 1.30 Å
- 2Y66 chain A against the predicted model P14900: TM-score 0.96, RMSD 1.30 Å
Elsewhere
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