UniProt P14867
Gamma-aminobutyric acid receptor subunit alpha-1 (P14867)
Gamma-aminobutyric acid receptor subunit alpha-1 (UniProt P14867): 37 experimental structures and 1 predicted model on GenesisL1, 35 ligands bound, 226 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P14867
- Protein
- Gamma-aminobutyric acid receptor subunit alpha-1
- Experimental structures
- 37
- Predicted models
- 1
- Ligands
- 35
- Pockets
- 226 · 14 records with a druggable one
Structures
38 records of P14867 in the MolNFT archive: 37 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6CDU | Crystal structure of a chimeric human alpha1GABAA receptor in complex with alphaxalone | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | EY4 | — |
| 6CDU | Crystal structure of a chimeric human ALPHA1GABAA receptor in complex with alphaxalone | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | EY4 | — |
| 6D1S | Crystal structure of an apo chimeric human ALPHA1GABAA receptor | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 6D6T | Human GABA-a receptor ALPHA1-BETA2-GAMMA2 subtype in complex with GABA and flumazenil, conformation… | electron microscopy | B, D | NAG, MAN, ABU, Y01, FYP | — |
| 6D6U | Human GABA-A receptor alpha1-beta2-gamma2 subtype in complex with GABA and flumazenil, conformation… | electron microscopy | B, D | NAG, MAN, ABU, Y01, FYP | 17 (best 0.86) |
| 6D6U | Human GABA-a receptor ALPHA1-BETA2-GAMMA2 subtype in complex with GABA and flumazenil, conformation… | electron microscopy | B, D | NAG, MAN, ABU, Y01, FYP | — |
| 6HUJ | CryoEM structure of human full-length heteromeric alpha1beta3gamma2L GABA(A)R in complex with… | electron microscopy | A, D | NAG, MAN, PIO, RI5, ABU | — |
| 6HUJ | Cryoem structure of human full-length heteromeric ALPHA1BETA3GAMMA2L GABA(A)R in complex with… | electron microscopy | A, D | NAG, MAN, PIO, RI5, ABU | — |
| 6HUK | CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with bicuculline and… | electron microscopy | A, D | NAG, MAN, H0Z, PIO | — |
| 6HUK | Cryoem structure of human full-length ALPHA1BETA3GAMMA2L GABA(A)R in complex with bicuculline and… | electron microscopy | A, D | NAG, MAN, H0Z, PIO | — |
| 6HUO | Cryoem structure of human full-length heteromeric ALPHA1BETA3GAMMA2L GABA(A)R in complex with… | electron microscopy | A, D | NAG, MAN, ABU, PIO, 08H | — |
| 6HUP | CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with diazepam… | electron microscopy | A, D | NAG, MAN, PIO, ABU, DZP | — |
| 6HUP | Cryoem structure of human full-length ALPHA1BETA3GAMMA2L GABA(A)R in complex with diazepam… | electron microscopy | A, D | NAG, MAN, PIO, ABU, DZP | — |
| 6I53 | Cryo-EM structure of the human synaptic alpha1-beta3-gamma2 GABAA receptor in complex with… | electron microscopy | A, D | NAG, PIO, POV | — |
| 6I53 | Cryo-EM structure of the human synaptic ALPHA1-BETA3-GAMMA2 gabaa receptor in complex with… | electron microscopy | A, D | NAG, PIO, POV | — |
| 6X3S | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with bicuculline methbromide | electron microscopy | B, D | NAG, MAN, J94 | 18 (best 0.80) |
| 6X3S | Human gabaa receptor ALPHA1-BETA2-GAMMA2 subtype in complex with bicuculline methbromide | electron microscopy | B, D | NAG, MAN, J94 | — |
| 6X3T | Human gabaa receptor ALPHA1-BETA2-GAMMA2 subtype in complex with GABA plus propofol | electron microscopy | B, D | NAG, MAN, ABU, PFL | — |
| 6X3U | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus flumazenil | electron microscopy | B, D | NAG, MAN, ABU, FYP | 17 (best 0.84) |
| 6X3U | Human gabaa receptor ALPHA1-BETA2-GAMMA2 subtype in complex with GABA plus flumazenil | electron microscopy | B, D | NAG, MAN, ABU, FYP | — |
| 6X3V | Human gabaa receptor ALPHA1-BETA2-GAMMA2 subtype in complex with GABA plus etomidate | electron microscopy | B, D | NAG, MAN, ABU, V8D | — |
| 6X3W | Human gabaa receptor ALPHA1-BETA2-GAMMA2 subtype in complex with GABA plus phenobarbital | electron microscopy | B, D | NAG, MAN, ABU, UQA | — |
| 6X3X | Human gabaa receptor ALPHA1-BETA2-GAMMA2 subtype in complex with GABA plus diazepam | electron microscopy | B, D | NAG, MAN, ABU, DZP | — |
| 6X3Z | Human gabaa receptor ALPHA1-BETA2-GAMMA2 subtype in complex with GABA | electron microscopy | B, D | NAG, MAN, ABU | — |
| 6X40 | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus picrotoxin | electron microscopy | B, D | NAG, MAN, ABU, RI5 | 17 (best 0.85) |
| 6X40 | Human gabaa receptor ALPHA1-BETA2-GAMMA2 subtype in complex with GABA plus picrotoxin | electron microscopy | B, D | NAG, MAN, ABU, RI5 | — |
| 7PC0 | GABA-A receptor bound by a-Cobratoxin | electron microscopy | A, D | NAG | 15 (best 0.77) |
| 7T0W | Complex of GABA-A synaptic receptor with autoimmune antibody Fab115 | electron microscopy | B, D | NAG, MAN | 16 (best 0.80) |
| 7T0Z | Complex of GABA-A synaptic receptor with autoimmune antibody Fab175 | electron microscopy | B, D | NAG, MAN, ABU | 17 (best 0.84) |
| 8DD2 | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus Zolpidem | electron microscopy | B, D | NAG, MAN, R5R, ABU | 16 (best 0.86) |
| 8DD2 | Human gabaa receptor ALPHA1-BETA2-GAMMA2 subtype in complex with GABA plus zolpidem | electron microscopy | B, D | NAG, MAN, R5R, ABU | — |
| 8DD3 | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus DMCM | electron microscopy | B, D | NAG, MAN, ABU, R63 | 17 (best 0.86) |
| 8SI9 | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus allopregnanolone | electron microscopy | B, D | NAG, MAN, Y4B, ABU | 16 (best 0.82) |
| 8SID | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus dehydroepiandrosterone… | electron microscopy | B, D | NAG, MAN, ABU, ZWY, PTY, POV | 17 (best 0.84) |
| 8VQY | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus methaqualone | electron microscopy | B, D | NAG, MAN, ABU, A1ADG, PTY, Q3G | 17 (best 0.86) |
| 9EQG | CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with GABA and puerarin | electron microscopy | A, D | NAG, MAN, PGW, D10, PT5, R16 | 17 (best 0.84) |
| 9H9E | Cryo-EM structure of the human GABAA receptor alpha1 subunit in complex with the assembly factor… | electron microscopy | A, D | NAG, MAN, PX6, PC7, PGT, CLR | 9 (best 0.73) |
| P14867 | AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor subunit alpha-1 (P14867) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 34 records
- MAN · alpha-D-mannopyranose · in 31 records
- ABU · Gamma-amino-butanoic acid · in 25 records
- PIO · [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2, 3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate · in 9 records
- FYP · Ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1, 5-a][1,4]benzodiazepine-3-carboxylate · in 5 records
- RI5 · (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3H)-dione · in 4 records
- DZP · 7-chloro-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one · in 3 records
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 3 records
- Y01 · Cholesterol hemisuccinate · in 3 records
- EY4 · (3a,5a)-3-Hydroxypregnane-11,20-dione · in 2 records
- H0Z · bicuculline methochloride · in 2 records
- J94 · (5S)-6,6-dimethyl-5-[(6R)-8-oxo-6,8-dihydrofuro[3,4-e][1,3]benzodioxol-6-yl]-5,6,7,8-tetrahydro[1, 3]dioxolo[4,5-g]isoquinolin-6-ium · in 2 records
- PTY · Phosphatidylethanolamine · in 2 records
- R5R · Zolpidem · in 2 records
- 08H · 8-chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-A][1, 4]benzodiazepine · in 1 record
- A1ADG · 2-methyl-3-(2-methylphenyl)quinazolin-4(3H)-one · in 1 record
- A1H6W · Puerarin · in 1 record
- CL · Chloride ion · in 1 record
- CLR · Cholesterol · in 1 record
- D10 · Decane · in 1 record
- PC7 · (7S)-4-hydroxy-N,N,N-trimethyl-9-oxo-7-[(palmitoyloxy) methyl]-3,5,8-trioxa-4-phosphahexacosan-1-aminium 4-oxide · in 1 record
- PFL · 2,6-bis(1-methylethyl)phenol · in 1 record
- PGT · (1S)-2-{[{[(2R)-2,3-dihydroxypropyl]oxy}(hydroxy) phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl stearate · in 1 record
- PGW · (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy) phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate · in 1 record
- PLM · Palmitic acid · in 1 record
- PT5 · (1S)-2-{[(R)-hydroxy{[(1r,2r,3s,4r,5r,6s)-2,3,6-trihydroxy-4,5-bis(phosphonooxy) cyclohexyl]oxy}phosphoryl]oxy}-1-[(octadecanoyloxy) methyl]ethyl (8E,11E)-icosa-5,8,11,14-tetraenoate · in 1 record
- PX2 · 1,2-dilauroyl-sn-glycero-3-phosphate · in 1 record
- PX6 · 1,2-dipalmitoyl-sn-glycero-3-phosphate · in 1 record
- Q3G · O-[(R)-[(2S)-2-(hexadecanoyloxy)-3-(octadecanoyloxy) propoxy](hydroxy)phosphoryl]-D-serine · in 1 record
- R16 · Hexadecane · in 1 record
Experiment against prediction
- 6HUJ chain A against the predicted model P14867: TM-score 0.99, RMSD 0.51 Å
- 6HUJ chain A against the predicted model P14867: TM-score 0.99, RMSD 0.51 Å
- 6HUJ chain A against the predicted model P08219: TM-score 0.99, RMSD 0.55 Å
- 6HUJ chain A against the predicted model P08219: TM-score 0.99, RMSD 0.55 Å
- 6HUK chain A against the predicted model P14867: TM-score 0.99, RMSD 0.57 Å
- 6HUK chain A against the predicted model P14867: TM-score 0.99, RMSD 0.57 Å
- 6HUJ chain D against the predicted model P14867: TM-score 0.99, RMSD 0.64 Å
- 6HUJ chain D against the predicted model P14867: TM-score 0.99, RMSD 0.64 Å
- 6HUK chain D against the predicted model P14867: TM-score 0.99, RMSD 0.67 Å
- 6HUK chain D against the predicted model P14867: TM-score 0.99, RMSD 0.67 Å
Elsewhere
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