UniProt P13501
C-C motif chemokine 5 (P13501)
C-C motif chemokine 5 (UniProt P13501): 41 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 14 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P13501
- Protein
- C-C motif chemokine 5
- Experimental structures
- 41
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 14 · 4 records with a druggable one
Structures
42 records of P13501 in the MolNFT archive: 41 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1B3A | Total chemical synthesis and high-resolution crystal structure of the potent anti-HIV protein… | x-ray diffraction | A, B | — | — |
| 1B3A | Total chemical synthesis and high-resolution crystal structure of the potent anti-HIV protein… | x-ray diffraction | A, B | — | — |
| 1EQT | MET-RANTES | x-ray diffraction | A, B | — | — |
| 1EQT | MET-RANTES | x-ray diffraction | A, B | — | — |
| 1HRJ | Human rantes, NMR, 13 structures | solution nmr | A, B | — | — |
| 1HRJ | Human rantes, NMR, 13 structures | solution nmr | A, B | — | — |
| 1RTN | Proton NMR assignments and solution conformation of rantes, a chemokine of the cc type | solution nmr | A, B | — | — |
| 1RTN | Proton NMR assignments and solution conformation of rantes, a chemokine of the cc type | solution nmr | A, B | — | — |
| 1RTO | Proton NMR assignments and solution conformation of rantes, a chemokine of the cc type | solution nmr | A, B | — | — |
| 1RTO | Proton NMR assignments and solution conformation of rantes, a chemokine of the cc type | solution nmr | A, B | — | — |
| 1U4L | human RANTES complexed to heparin-derived disaccharide I-S | x-ray diffraction | A, B | — | — |
| 1U4L | Human rantes complexed to heparin-derived disaccharide I-S | x-ray diffraction | A, B | — | — |
| 1U4M | human RANTES complexed to heparin-derived disaccharide III-S | x-ray diffraction | A, B | — | — |
| 1U4M | Human rantes complexed to heparin-derived disaccharide III-S | x-ray diffraction | A, B | — | — |
| 1U4P | Crystal Structure of human RANTES mutant K45E | x-ray diffraction | A, B | — | — |
| 1U4P | Crystal structure of human rantes mutant K45E | x-ray diffraction | A, B | — | — |
| 1U4R | Crystal Structure of human RANTES mutant 44-AANA-47 | x-ray diffraction | A, B, C, D | — | — |
| 1U4R | Crystal structure of human rantes mutant 44-aana-47 | x-ray diffraction | A, B, C, D | — | — |
| 2L9H | Oligomeric Structure of the Chemokine CCL5/RANTES from NMR, MS, and SAXS Data | solution nmr, solution scattering | A, B, C, D | — | — |
| 2L9H | Oligomeric structure of the chemokine CCL5/RANTES from NMR, ms, and saxs data | solution nmr; solution scattering | A, B, C, D | — | — |
| 2VXW | Structural and Functional Studies of the Potent Anti-HIV Chemokine Variant P2-RANTES | x-ray diffraction | A, B, C, D | — | — |
| 2VXW | Structural and functional studies of the potent anti-HIV chemokine variant P2-rantes | x-ray diffraction | A, B, C, D | — | — |
| 5CMD | Oligomer crystal structure of CC chemokine 5 (CCL5) | x-ray diffraction | A, B, C, D, E, F | SO4 | 5 (best 0.69) |
| 5CMD | Oligomer crystal structure of cc chemokine 5 (CCL5) | x-ray diffraction | A, B, C, D, E, F | — | — |
| 5COY | Crystal structure of CC chemokine 5 (CCL5) | x-ray diffraction | A, B | GLC, Z9N, PO4 | — |
| 5COY | Crystal structure of cc chemokine 5 (CCL5) | x-ray diffraction | A, B | — | — |
| 5DNF | Crystal structure of CC chemokine 5 (CCL5) oligomer in complex with heparin | x-ray diffraction | A, B, C, D, E, F, G, H, I | SGN, IDS, GLA, BGC, SO4, CL | — |
| 5DNF | Crystal structure of cc chemokine 5 (CCL5) oligomer in complex with heparin | x-ray diffraction | A, B, C, D, E, F, G, H, I | — | — |
| 5L2U | Oligomer crystal structure of CC chemokine 5 (CCL5) | x-ray diffraction | A, B, C, D, E, F, G, H, I | CL | 3 (best 0.57) |
| 5L2U | Oligomer crystal structure of cc chemokine 5 (CCL5) | x-ray diffraction | A, B, C, D, E, F, G, H, I | CL | — |
| 5UIW | Crystal structure of cc chemokine receptor 5 (CCR5) in complex with high potency HIV entry… | x-ray diffraction | B | — | — |
| 6AEZ | Crystal structure of human CCL5 trimer | x-ray diffraction | A, B, C | SO4 | — |
| 6C6D | 20MER crystal structure of cc chemokine 5 (CCL5) | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, S, T, M, N, O, P, Q, R | — | — |
| 6FGP | NMR solution structure of monomeric CCL5 in complex with a doubly- sulfated N-terminal segment of… | solution nmr | B | — | — |
| 6LOG | Crystal structure of human CCL5-12AAA14 mutant | x-ray diffraction | A | — | — |
| 6STK | Crystal structure of the CC-chemokine 5 (CCL5) E66S mutation | x-ray diffraction | A, B | — | — |
| 6STK | Crystal structure of the cc-chemokine 5 (CCL5) E66S mutation | x-ray diffraction | A, B | — | — |
| 7F1R | Cryo-EM structure of the chemokine receptor CCR5 in complex with RANTES and Gi | electron microscopy | R | — | 4 (best 0.79) |
| 7F1R | Cryo-EM structure of the chemokine receptor CCR5 in complex with rantes and gi | electron microscopy | R | — | — |
| 7O7F | Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist | electron microscopy | I | — | 2 (best 0.63) |
| 7O7F | Structural basis of the activation of the cc chemokine receptor 5 by a chemokine agonist | electron microscopy | I | — | — |
| P13501 | AlphaFold monomer V2.0 prediction for C-C motif chemokine 5 (P13501) | predicted | A | — | — |
Ligands
- CL · Chloride ion · in 3 records
- SO4 · Sulfate ion · in 3 records
- BGC · beta-D-glucopyranose · in 1 record
- GLA · alpha-D-galactopyranose · in 1 record
- GLC · alpha-D-glucopyranose · in 1 record
- IDS · 2-O-sulfo-alpha-L-idopyranuronic acid · in 1 record
- PO4 · Phosphate ion · in 1 record
- SGN · 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose · in 1 record
- Z9N · alpha-D-fructofuranose · in 1 record
Experiment against prediction
- 5L2U chain F against the predicted model P13501: TM-score 0.97, RMSD 0.76 Å
- 5L2U chain F against the predicted model P13501: TM-score 0.97, RMSD 0.76 Å
- 5L2U chain G against the predicted model P13501: TM-score 0.97, RMSD 0.78 Å
- 5L2U chain G against the predicted model P13501: TM-score 0.97, RMSD 0.78 Å
- 5L2U chain D against the predicted model P13501: TM-score 0.96, RMSD 0.70 Å
- 5L2U chain D against the predicted model P13501: TM-score 0.96, RMSD 0.70 Å
- 5CMD chain A against the predicted model P13501: TM-score 0.96, RMSD 0.60 Å
- 5CMD chain A against the predicted model P13501: TM-score 0.96, RMSD 0.60 Å
- 6C6D chain T against the predicted model P13501: TM-score 0.96, RMSD 0.57 Å
- 5L2U chain I against the predicted model P13501: TM-score 0.96, RMSD 0.73 Å
Elsewhere
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