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Ligand · GLA

GLA · alpha-D-galactopyranose

GLA, alpha-D-galactopyranose (C6 H12 O6, 180.2 g/mol), in the MolNFT structures on GenesisL1: bound in 143 records (107 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with…

Component
GLA
Formula
C6 H12 O6
Class
sugar
Structures
143
PDB entries
107

Binding sites

GLA in 143 structures; the first of them:

  • 4XKW · Tailspike protein mutant D339N of E. coli bacteriophage HK620 in complex with… · GLA B2 · binds LEU282, THR307, TRP308, ASN339, TYR344, HIS397, GLU400, ASN471
  • 4XN3 · Tailspike protein mutant E372A of E. coli bacteriophage HK620 in complex with… · GLA B2 · binds LEU282, THR307, TRP308, ASP339, TYR344, HIS397, GLU400
  • 4XOT · Tailspike protein mutant E372Q of E. coli bacteriophage HK620 in complex with… · GLA B2 · binds LEU282, THR307, TRP308, ASP339, TYR344, HIS397, GLU400, ASN471
  • 4XPS · Crystal structure of the mutant D365A of Pedobacter saltans GH31 alpha-galactosidase… · GLA A1001 · binds GLU266, PRO267, TYR274, TRP305, LYS363, GLU366, ARG418, TYR432 and 3 more
  • 4Z3G · Crystal structure of the lectin domain of PapG from E. coli BI47 in complex with… · GLA C2 · binds GLU59, ILE61, SER89, GLU91, LEU102, LYS103, GLY104, LYS172
  • 4Z4Y · Crystal structure of GII.10 P domain in complex with 7.5mM B antigen (trisaccharide) · GLA C1 · binds GLY451
  • 4ZFW · Structural studies on a non-toxic homologue of type II RIPs from Momordica charantia… · GLA B301 · binds ASP22, VAL23, TYR24, GLY25, TYR37, GLN42, ASN44, ARG112
  • 4ZS9 · Raffinose and panose binding protein from Bifidobacterium animalis subsp. lactis Bl-04… · GLA C3 · binds ASN109, GLY110, ASP111, ASN165, TRP216, GLN219, ALA220, TYR291 and 3 more
  • 4ZZA · Raffinose and panose binding protein from Bifidobacterium animalis subsp. lactis Bl-04… · GLA C3 · binds ASN109, GLY110, ASP111, ASN165, TRP216, GLN219, ALA220, TYR291 and 3 more
  • 5CB7 · Crystallographic structure of human rotavirus K8 VP8* in complex with A-type HBGA · GLA C1 · binds SER187, TYR188, TYR189
  • 5D61 · MOA-Z-VAD-fmk complex, direct orientation · GLA B3 · binds TRP35, GLN36, PHE37, THR38, ASN43, GLN46
  • 5D62 · MOA-Z-VAD-fmk complex, inverted orientation · GLA B3 · binds TRP35, GLN36, PHE37, THR38, ASN43, GLN46
  • 5D63 · MOA-Z-VAD-fmk inhibitor complex, direct/inverted dual orientation · GLA B3 · binds TRP35, GLN36, PHE37, THR38, ASN43, GLN46
  • 5DNF · Crystal structure of CC chemokine 5 (CCL5) oligomer in complex with heparin · GLA A101 · binds SER4, SER5, PRO9, GLU26, PHE28, GLN48
  • 5E1Q · Mutant (D415G) GH97 alpha-galactosidase in complex with Gal-Lac · GLA C2 · binds TRP310, TRP312, ASP350, GLU351, TRP387, LYS413, PHE416, HIS445 and 2 more
  • 5ELB · Cholera toxin classical B-pentamer in complex with Lewis-y · GLA A203 · binds GLU51, GLN56, HIS57, GLN61, TRP88, ASN90, LYS91

Residues it binds most

TRP 204, ASP 218, GLY 168, ASN 216, TYR 188, GLU 182, HIS 125, GLN 117, ARG 118, LYS 99 (residue and the binding sites it lines).

Found with

  • GAL · beta-D-galactopyranose
  • EDO · 1,2-ethanediol
  • FUC · alpha-L-fucopyranose
  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
  • NA · Sodium ion
  • CA · Calcium ion
  • GLC · alpha-D-glucopyranose
  • CL · Chloride ion
  • BGC · beta-D-glucopyranose
  • GOL · Glycerol
  • PEG · Di(hydroxyethyl)ether
  • FRU · beta-D-fructofuranose

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