Crystal structure of cc chemokine receptor 5 (CCR5) in complex with high potency HIV entry inhibitor 5P7-CCL5

Structure

x-ray diffraction · 2 distinct chains.

Ligands and binding sites

• OLA · Oleic acid · ligand · 2 copies · chains A
• ZN · Zinc ion · metal · chains A
• OLC · (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate · additive · 6 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 5UIW · Crystal Structure of CC Chemokine Receptor 5 (CCR5) in complex with high potency HIV… · the same entry in another collection · chain A against A, TM-score 1.00
• P13501 · AlphaFold monomer V2.0 prediction for C-C motif chemokine 5 (P13501) · a predicted model of the same protein · chain B against A, TM-score 0.89
• P51681 · AlphaFold monomer V2.0 prediction for C-C chemokine receptor type 5 (P51681) · a predicted model of the same protein · chain A against A, TM-score 0.85
• P00268 · AlphaFold monomer V2.0 prediction for rubredoxin (P00268) · a predicted model of the same protein · chain A against A, TM-score 0.15

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P51681
• Every structure of UniProt P00268
• Every structure of UniProt P13501
• Elsewhere: RCSB PDB 5UIW · PDBe 5UIW · UniProt P51681 · UniProt P00268 · UniProt P13501