UniProt P51681
C-C chemokine receptor type 5 (P51681)
C-C chemokine receptor type 5 (UniProt P51681): 27 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 3 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P51681
- Protein
- C-C chemokine receptor type 5
- Experimental structures
- 27
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 3 · 1 record with a druggable one
Structures
28 records of P51681 in the MolNFT archive: 27 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2L87 | The 27-residue N-terminus CCR5-peptide in a ternary complex with HIV-1 gp120 and a CD4-mimic peptide | solution nmr | A | — | — |
| 2L87 | The 27-residue N-terminus CCR5-peptide in a ternary complex with HIV-1 GP120 and a CD4-mimic peptide | solution nmr | A | — | — |
| 2MZX | CCR5-ECL2 helical structure, residues Q186-T195 | solution nmr | A | — | — |
| 2MZX | CCR5-ECL2 helical structure, residues Q186-T195 | solution nmr | A | — | — |
| 2RLL | CCR5 Nt(7-15) | solution nmr | A | — | — |
| 2RLL | CCR5 NT(7-15) | solution nmr | A | — | — |
| 2RRS | NMR Structure of LC4 transmembrane segment of CCR5 | solution nmr | A | — | — |
| 2RRS | NMR structure of LC4 transmembrane segment of CCR5 | solution nmr | A | — | — |
| 4MBS | Crystal Structure of the CCR5 Chemokine Receptor | x-ray diffraction | A, B | — | — |
| 4MBS | Crystal structure of the CCR5 chemokine receptor | x-ray diffraction | A, B | — | — |
| 5UIW | Crystal structure of cc chemokine receptor 5 (CCR5) in complex with high potency HIV entry… | x-ray diffraction | A | ZN, OLA | — |
| 5YY4 | Crystal structure of the scfv antibody 4B08 with sulfated epitope peptide | x-ray diffraction | B | — | — |
| 6AKX | The crystal structure of human chemokine receptor CCR5 in complex with compound 21 | x-ray diffraction | A, B | ZN, NO3, A4R | — |
| 6AKY | The crystal structure of human chemokine receptor CCR5 in complex with compound 34 | x-ray diffraction | A | ZN, A4X | — |
| 6FGP | NMR solution structure of monomeric CCL5 in complex with a doubly- sulfated N-terminal segment of… | solution nmr | A | — | — |
| 6MEO | Structural basis of coreceptor recognition by HIV-1 envelope spike | electron microscopy | B | A2G | — |
| 6MEO | Structural basis of coreceptor recognition by HIV-1 envelope spike | electron microscopy | B | A2G | — |
| 6MET | Structural basis of coreceptor recognition by HIV-1 envelope spike | electron microscopy | B | A2G | — |
| 6MET | Structural basis of coreceptor recognition by HIV-1 envelope spike | electron microscopy | B | A2G | — |
| 7F1Q | Cryo-EM structure of the chemokine receptor CCR5 in complex with mip- 1A and gi | electron microscopy | R | — | — |
| 7F1R | Cryo-EM structure of the chemokine receptor CCR5 in complex with rantes and gi | electron microscopy | R | — | — |
| 7F1S | Cryo-EM structure of the apo chemokine receptor CCR5 in complex with gi | electron microscopy | R | — | — |
| 7F1T | Crystal structure of the human chemokine receptor CCR5 in complex with mip-1A | x-ray diffraction | A | ZN | — |
| 7NJZ | X-ray crystallography study of ROAB13 which binds to piydin, a part of the CCR5 N terminal domain | x-ray diffraction | C | — | — |
| 7NW3 | X-ray crystallographic study of piydin, which contains the truncation determinants of binding pi… | x-ray diffraction | A | — | — |
| 7O7F | Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist | electron microscopy | C | — | 3 (best 0.72) |
| 7O7F | Structural basis of the activation of the cc chemokine receptor 5 by a chemokine agonist | electron microscopy | C | — | — |
| P51681 | AlphaFold monomer V2.0 prediction for C-C chemokine receptor type 5 (P51681) | predicted | A | — | — |
Ligands
- A2G · 2-acetamido-2-deoxy-alpha-D-galactopyranose · in 4 records
- ZN · Zinc ion · in 4 records
- A4R · N-[(1S)-3-{(3-exo)-3-[3-methyl-5-(propan-2-yl)-4H-1,2, 4-triazol-4-yl]-8-azabicyclo[3.2.1]octan-8-yl}-1-(thiophen-2-yl)propyl]cyclopentanecarboxamide · in 1 record
- A4X · 4,4-difluoro-N-[(1S)-3-{(3-exo)-3-[3-methyl-5-(propan-2-yl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]octan-8-yl}-1-(thiophen-3-yl)propyl]cyclohexane-1-carboxamide · in 1 record
- NO3 · Nitrate ion · in 1 record
- OLA · Oleic acid · in 1 record
Experiment against prediction
- 7O7F chain C against the predicted model P51681: TM-score 0.93, RMSD 2.10 Å
- 7O7F chain C against the predicted model P51681: TM-score 0.93, RMSD 2.10 Å
- 6MEO chain B against the predicted model P51681: TM-score 0.92, RMSD 2.36 Å
- 6MET chain B against the predicted model P51681: TM-score 0.92, RMSD 2.36 Å
- 6MEO chain B against the predicted model P51681: TM-score 0.92, RMSD 2.36 Å
- 6MET chain B against the predicted model P51681: TM-score 0.92, RMSD 2.36 Å
- 7F1S chain R against the predicted model P51681: TM-score 0.89, RMSD 2.52 Å
- 5UIW chain A against the predicted model P51681: TM-score 0.85, RMSD 0.74 Å
- 6AKY chain A against the predicted model P51681: TM-score 0.83, RMSD 1.17 Å
- 6AKX chain B against the predicted model P51681: TM-score 0.83, RMSD 1.28 Å
Elsewhere
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