UniProt P00268
P2Y purinoceptor 1, Rubredoxin, P2Y purinoceptor 1 (P00268)
P2Y purinoceptor 1, Rubredoxin, P2Y purinoceptor 1 (UniProt P00268): 74 experimental structures on GenesisL1, 19 ligands bound, 1 pocket. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P00268
- Protein
- P2Y purinoceptor 1, Rubredoxin, P2Y purinoceptor 1
- Experimental structures
- 74
- Predicted models
- 0
- Ligands
- 19
- Pockets
- 1 · 1 record with a druggable one
Structures
74 records of P00268 in the MolNFT archive: 74 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1B13 | Clostridium pasteurianum rubredoxin G10A mutant | x-ray diffraction | A | — | — |
| 1B13 | Clostridium pasteurianum rubredoxin G10A mutant | x-ray diffraction | A | — | — |
| 1B2J | Clostridium pasteurianum rubredoxin G43A mutant | x-ray diffraction | A | — | — |
| 1B2J | Clostridium pasteurianum rubredoxin G43A mutant | x-ray diffraction | A | — | — |
| 1B2O | Clostridium pasteurianum rubredoxin G10VG43A mutant | x-ray diffraction | A, B | — | — |
| 1B2O | Clostridium pasteurianum rubredoxin G10VG43A mutant | x-ray diffraction | A, B | — | — |
| 1BE7 | Clostridium pasteurianum rubredoxin C42S mutant | x-ray diffraction | A | — | — |
| 1BE7 | Clostridium pasteurianum rubredoxin C42S mutant | x-ray diffraction | A | — | — |
| 1BFY | Solution structure of reduced clostridium pasteurianum rubredoxin, NMR, 20 structures | solution nmr | A | — | — |
| 1BFY | Solution structure of reduced clostridium pasteurianum rubredoxin, NMR, 20 structures | solution nmr | A | — | — |
| 1C09 | Rubredoxin V44A cp | x-ray diffraction | A, B, C | — | — |
| 1C09 | Rubredoxin V44A cp | x-ray diffraction | A, B, C | — | — |
| 1FHH | X-ray crystal structure of oxidized rubredoxin | x-ray diffraction | A | — | — |
| 1FHH | X-ray crystal structure of oxidized rubredoxin | x-ray diffraction | A | — | — |
| 1FHM | X-ray crystal structure of reduced rubredoxin | x-ray diffraction | A | — | — |
| 1FHM | X-ray crystal structure of reduced rubredoxin | x-ray diffraction | A | — | — |
| 1IRN | Rubredoxin (zn-substituted) at 1.2 ångströms resolution | x-ray diffraction | A | — | — |
| 1IRN | Rubredoxin (zn-substituted) at 1.2 ångströms resolution | x-ray diffraction | A | — | — |
| 1IRO | Rubredoxin (oxidized, FE(III)) at 1.1 ångströms resolution | x-ray diffraction | A | — | — |
| 1IRO | Rubredoxin (oxidized, FE(III)) at 1.1 ångströms resolution | x-ray diffraction | A | — | — |
| 1R0F | Gallium-substituted rubredoxin | x-ray diffraction | A | — | — |
| 1R0F | Gallium-substituted rubredoxin | x-ray diffraction | A | — | — |
| 1R0G | mercury-substituted rubredoxin | x-ray diffraction | A | — | — |
| 1R0G | Mercury-substituted rubredoxin | x-ray diffraction | A | — | — |
| 1R0H | cobalt-substituted rubredoxin | x-ray diffraction | A | — | — |
| 1R0H | Cobalt-substituted rubredoxin | x-ray diffraction | A | — | — |
| 1R0I | cadmium-substituted rubredoxin | x-ray diffraction | A | — | — |
| 1R0I | Cadmium-substituted rubredoxin | x-ray diffraction | A | — | — |
| 1R0J | nickel-substituted rubredoxin | x-ray diffraction | A | — | — |
| 1R0J | Nickel-substituted rubredoxin | x-ray diffraction | A | — | — |
| 1SMM | Crystal Structure of Cp Rd L41A mutant in oxidized state | x-ray diffraction | A | — | — |
| 1SMM | Crystal structure of cp rd L41A mutant in oxidized state | x-ray diffraction | A | — | — |
| 1SMU | Crystal Structure of Cp Rd L41A mutant in reduced state 1 (drop-reduced) | x-ray diffraction | A | — | — |
| 1SMU | Crystal structure of cp rd L41A mutant in reduced state 1 (drop- reduced) | x-ray diffraction | A | — | — |
| 1SMW | Crystal Structure of Cp Rd L41A mutant in reduced state 2 (soaked) | x-ray diffraction | A | — | — |
| 1SMW | Crystal structure of cp rd L41A mutant in reduced state 2 (soaked) | x-ray diffraction | A | — | — |
| 1T9O | Crystal Structure of V44G Cp Rubredoxin | x-ray diffraction | A, B, C | — | — |
| 1T9O | Crystal structure of V44G cp rubredoxin | x-ray diffraction | A, B, C | — | — |
| 1T9P | Crystal Structure of V44A, G45P Cp Rubredoxin | x-ray diffraction | A, B, C | — | — |
| 1T9P | Crystal structure of V44A, G45P cp rubredoxin | x-ray diffraction | A, B, C | — | — |
| 1T9Q | Crystal Structure of V44L Cp Rubredoxin | x-ray diffraction | A | — | — |
| 1T9Q | Crystal structure of V44L cp rubredoxin | x-ray diffraction | A | — | — |
| 2PVE | NMR and X-ray Analysis of Structural Additivity in Metal Binding Site-Swapped Hybrids of Rubredoxin | x-ray diffraction | A, B, C | — | — |
| 2PVE | NMR and X-ray analysis of structural additivity in metal binding site- swapped hybrids of rubredoxin | x-ray diffraction | A, B, C | — | — |
| 4MBS | Crystal Structure of the CCR5 Chemokine Receptor | x-ray diffraction | A, B | — | — |
| 4MBS | Crystal structure of the CCR5 chemokine receptor | x-ray diffraction | A, B | — | — |
| 4RXN | Crystallographic refinement of rubredoxin at 1.2 ångströms resolution | x-ray diffraction | A | — | — |
| 4RXN | Crystallographic refinement of rubredoxin at 1.2 ångströms resolution | x-ray diffraction | A | — | — |
| 4XNV | The human P2Y1 receptor in complex with BPTU | x-ray diffraction | A | BUR, CLR, Y01, ZN | 1 (best 0.67) |
| 4XNV | The human P2Y1 receptor in complex with bptu | x-ray diffraction | A | — | — |
| 4XNW | The human P2Y1 receptor in complex with MRS2500 | x-ray diffraction | A, C | — | — |
| 4XNW | The human P2Y1 receptor in complex with MRS2500 | x-ray diffraction | A, C | — | — |
| 5RXN | Combined crystallographic refinement and energy minimization of rubredoxin at 1.2 ångström… | x-ray diffraction | A | FE | — |
| 5UIW | Crystal structure of cc chemokine receptor 5 (CCR5) in complex with high potency HIV entry… | x-ray diffraction | A | ZN, OLA | — |
| 5VBL | Structure of apelin receptor in complex with agonist peptide | x-ray diffraction | B | ZN | — |
| 6AKX | The crystal structure of human chemokine receptor CCR5 in complex with compound 21 | x-ray diffraction | A, B | ZN, NO3, A4R | — |
| 6AKY | The crystal structure of human chemokine receptor CCR5 in complex with compound 34 | x-ray diffraction | A | ZN, A4X | — |
| 6BD4 | Crystal structure of human apo-FRIZZLED4 receptor | x-ray diffraction | A | ZN, OLA, SO4, UNX | — |
| 6GPS | Crystal structure of CCR2A in complex with mk-0812 | x-ray diffraction | A | ZN, F7N | — |
| 6GPS | Crystal structure of CCR2A in complex with mk-0812 | x-ray diffraction | A | ZN, F7N | — |
14 records more on the page itself.
Ligands
- ZN · Zinc ion · in 21 records
- CLR · Cholesterol · in 3 records
- F7N · [(3~{S},4~{S})-3-methoxyoxan-4-yl]-[(1~{R},3~{S})-3-propan-2-yl-3-[[3-(trifluoromethyl)-7,8-dihydro-5~{H}-1,6-naphthyridin-6-yl]carbonyl]cyclopentyl]azanium · in 3 records
- JEY · N-[2-(5-methoxy-2-phenyl-1H-indol-3-yl)ethyl]acetamide · in 3 records
- OLA · Oleic acid · in 3 records
- JEV · N-{2-[(8S)-1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl}propanamide · in 2 records
- 8EH · (1R,2S)-N-[4-(2,6-dimethoxyphenyl)-5-(6-methylpyridin-2-yl)-1,2,4-triazol-3-yl]-1-(5-methylpyrimidin-2-yl)-1-oxidanyl-propane-2-sulfonamide · in 1 record
- 97Y · N-{4-[(R)-(3,3-dimethylcyclobutyl)({6-[4-(trifluoromethyl)-1H-imidazol-1-yl]pyridin-3-yl}amino)methyl]benzene-1-carbonyl}-beta-alanine · in 1 record
- A4R · N-[(1S)-3-{(3-exo)-3-[3-methyl-5-(propan-2-yl)-4H-1,2, 4-triazol-4-yl]-8-azabicyclo[3.2.1]octan-8-yl}-1-(thiophen-2-yl)propyl]cyclopentanecarboxamide · in 1 record
- A4X · 4,4-difluoro-N-[(1S)-3-{(3-exo)-3-[3-methyl-5-(propan-2-yl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]octan-8-yl}-1-(thiophen-3-yl)propyl]cyclohexane-1-carboxamide · in 1 record
- A8X · 3-[(3R)-3-[(4-fluorophenyl)sulfonylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]propanoic acid · in 1 record
- A90 · 2-[4-[2-[(4-chlorophenyl) sulfonylamino]ethyl]phenyl]ethanoic acid · in 1 record
- BUR · 1-[2-(2-tert-butylphenoxy)pyridin-3-yl]-3-[4-(trifluoromethoxy)phenyl]urea · in 1 record
- FE · Fe (III) ion · in 1 record
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 1 record
- NO3 · Nitrate ion · in 1 record
- SO4 · Sulfate ion · in 1 record
- UNX · Unknown atom or ion · in 1 record
- Y01 · Cholesterol hemisuccinate · in 1 record
Experiment against prediction
- 6GPX chain B against the predicted model P41597: TM-score 0.98, RMSD 1.03 Å
- 5VBL chain B against the predicted model P35414: TM-score 0.85, RMSD 1.77 Å
- 5UIW chain A against the predicted model P51681: TM-score 0.85, RMSD 0.74 Å
- 6BD4 chain A against the predicted model Q9ULV1: TM-score 0.84, RMSD 1.62 Å
- 7SUS chain A against the predicted model P35414: TM-score 0.83, RMSD 2.01 Å
- 6KNM chain B against the predicted model P35414: TM-score 0.83, RMSD 1.98 Å
- 6AKY chain A against the predicted model P51681: TM-score 0.83, RMSD 1.17 Å
- 6GPX chain A against the predicted model P41597: TM-score 0.83, RMSD 1.21 Å
- 6AKX chain B against the predicted model P51681: TM-score 0.83, RMSD 1.28 Å
- 4MBS chain B against the predicted model P51681: TM-score 0.83, RMSD 1.41 Å
Elsewhere
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