MolNFT v1 · #178012 · protein
Cryo-EM structure of the chemokine receptor CCR5 in complex with rantes and gi
7F1R · C-C motif chemokine 5,C-C chemokine receptor type 5: “Cryo-EM structure of the chemokine receptor CCR5 in complex with rantes and gi”. Electron microscopy, 6 pockets (best druggability 0.82). MolNFT v1 #178012 on GenesisL1: 3D…
- PDB
- 7F1R
- Type
- protein
- Length
- 894 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- C-C motif chemokine 5,C-C chemokine receptor type 5; Guanine nucleotide-binding protein…
- UniProt
- P13501, P51681, P63096, P62873, P59768
- Pockets
- 6 · best druggability 0.82
Structure
electron microscopy · 4 distinct chains · 39% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| R | C-C motif chemokine 5,C-C chemokine receptor type 5 | protein | 327 | 72% helix, 2% strand | P13501, P51681 |
| A | Guanine nucleotide-binding protein G(I) subunit alpha-1 | protein | 216 | 44% helix, 17% strand | P63096 |
| B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | protein | 316 | 2% helix, 50% strand | P62873 |
| C | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | protein | 35 | 43% helix, 0% strand | P59768 |
Pockets
6 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 626 | 0.82 | 0.87 | 66 | empty |
| 2 | 331 | 0.79 | 0.89 | 56 | empty |
| 3 | 1086 | 0.76 | 0.78 | 74 | empty |
| 4 | 78 | 0.61 | 0.89 | 26 | empty |
| 5 | 182 | 0.58 | 0.81 | 27 | empty |
Interfaces
4 interfaces between chains.
- B–C · 1352 Ų buried · 3 hydrogen bonds · protein-protein
- A–B · 1230 Ų buried · 15 hydrogen bonds · protein-protein
- R–A · 1123 Ų buried · 7 hydrogen bonds · protein-protein
- R–B · 91 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 7F1R · Cryo-EM structure of the chemokine receptor CCR5 in complex with RANTES and Gi · the same entry in another collection · chain A against A, TM-score 1.00
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain C against A, TM-score 0.89
- P63096 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.82
- P51681 · AlphaFold monomer V2.0 prediction for C-C chemokine receptor type 5 (P51681) · a predicted model of the same protein · chain R against A, TM-score 0.77
- P13501 · AlphaFold monomer V2.0 prediction for C-C motif chemokine 5 (P13501) · a predicted model of the same protein · chain R against A, TM-score 0.13
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13501
- Every structure of UniProt P51681
- Every structure of UniProt P63096
- Every structure of UniProt P62873
- Every structure of UniProt P59768
- Elsewhere: RCSB PDB 7F1R · PDBe 7F1R · UniProt P13501 · UniProt P51681 · UniProt P63096 · UniProt P62873 · UniProt P59768
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