MolNFT v1 · #23586 · protein

Human rantes complexed to heparin-derived disaccharide III-S

1U4M · Small inducible cytokine A5: “Human rantes complexed to heparin-derived disaccharide III-S”. X-ray diffraction, 2 ligands (GNS, UAP). MolNFT v1 #23586 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1U4M
Type: protein
Length: 132 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Small inducible cytokine A5
UniProt: P13501
Ligands: GNS, UAP

Structure

x-ray diffraction · 2 distinct chains · 21% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Small inducible cytokine A5	protein	67	19% helix, 28% strand	P13501
B	Small inducible cytokine A5	protein	65	23% helix, 28% strand	P13501

Ligands and binding sites

GNS · 2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose · ligand · chains A
UAP · 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid · ligand · chains A
ACY · Acetic acid · additive · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 801 Å² buried · 12 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

1U4M · human RANTES complexed to heparin-derived disaccharide III-S · the same entry in another collection · chain A against A, TM-score 1.00
P13501 · AlphaFold monomer V2.0 prediction for C-C motif chemokine 5 (P13501) · a predicted model of the same protein · chain B against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P13501
Elsewhere: RCSB PDB 1U4M · PDBe 1U4M · UniProt P13501

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