UniProt P07949
Proto-oncogene tyrosine-protein kinase receptor Ret (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (UniProt P07949), EC 2.7.10.1: 63 experimental structures on GenesisL1, 17 ligands bound, 64 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P07949
- Protein
- Proto-oncogene tyrosine-protein kinase receptor Ret
- EC
- 2.7.10.1
- Experimental structures
- 63
- Predicted models
- 0
- Ligands
- 17
- Pockets
- 64 · 11 records with a druggable one
Structures
63 records of P07949 in the MolNFT archive: 63 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2IVS | Crystal structure of non-phosphorylated RET tyrosine kinase domain | x-ray diffraction | A, B | — | — |
| 2IVS | Crystal structure of non-phosphorylated ret tyrosine kinase domain | x-ray diffraction | A, B | — | — |
| 2IVT | Crystal structure of phosphorylated RET tyrosine kinase domain | x-ray diffraction | A | — | — |
| 2IVT | Crystal structure of phosphorylated ret tyrosine kinase domain | x-ray diffraction | A | — | — |
| 2IVU | Crystal structure of phosphorylated RET tyrosine kinase domain complexed with the inhibitor ZD6474 | x-ray diffraction | A | — | — |
| 2IVU | Crystal structure of phosphorylated ret tyrosine kinase domain complexed with the inhibitor ZD6474 | x-ray diffraction | A | — | — |
| 2IVV | Crystal structure of phosphorylated RET tyrosine kinase domain complexed with the inhibitor PP1 | x-ray diffraction | A | — | — |
| 2IVV | Crystal structure of phosphorylated ret tyrosine kinase domain complexed with the inhibitor PP1 | x-ray diffraction | A | — | — |
| 2X2K | Crystal Structure of phosphorylated RET tyrosine kinase domain with inhibitor | x-ray diffraction | A | — | — |
| 2X2K | Crystal structure of phosphorylated ret tyrosine kinase domain with inhibitor | x-ray diffraction | A | — | — |
| 2X2L | Crystal Structure of phosphorylated RET tyrosine kinase domain with inhibitor | x-ray diffraction | A | — | — |
| 2X2L | Crystal structure of phosphorylated ret tyrosine kinase domain with inhibitor | x-ray diffraction | A | — | — |
| 2X2M | Crystal Structure of phosphorylated RET tyrosine kinase domain with inhibitor | x-ray diffraction | A, B | — | — |
| 2X2M | Crystal structure of phosphorylated ret tyrosine kinase domain with inhibitor | x-ray diffraction | A, B | — | — |
| 2X2U | First two Cadherin-like domains from Human RET | x-ray diffraction | A | — | — |
| 2X2U | First two cadherin-like domains from human ret | x-ray diffraction | A | — | — |
| 4CKI | Crystal Structure of oncogenic RET tyrosine kinase M918T bound to adenosine | x-ray diffraction | A | — | — |
| 4CKI | Crystal structure of oncogenic ret tyrosine kinase M918T bound to adenosine | x-ray diffraction | A | — | — |
| 4CKJ | Crystal structure of RET tyrosine kinase domain bound to adenosine | x-ray diffraction | A | — | — |
| 4CKJ | Crystal structure of ret tyrosine kinase domain bound to adenosine | x-ray diffraction | A | — | — |
| 4UX8 | RET recognition of GDNF-GFRalpha1 ligand by a composite binding site promotes membrane-proximal… | electron microscopy | A, B | — | — |
| 4UX8 | Ret recognition of gdnf-GFRALPHA1 ligand by a composite binding site promotes membrane-proximal… | electron microscopy | A, B | — | — |
| 5AMN | The Discovery of 2-Substituted Phenol Quinazolines as Potent and Selective RET Kinase Inhibitors | x-ray diffraction | A | — | — |
| 5AMN | The discovery of 2-substituted phenol quinazolines as potent and selective ret kinase inhibitors | x-ray diffraction | A | — | — |
| 5FM2 | Crystal structure of hyper-phosphorylated RET kinase domain with (proximal) juxtamembrane segment | x-ray diffraction | A | PP1 | — |
| 5FM2 | Crystal structure of hyper-phosphorylated ret kinase domain with (proximal) juxtamembrane segment | x-ray diffraction | A | — | — |
| 5FM3 | Crystal structure of hyper-phosphorylated RET kinase domain with (proximal) juxtamembrane segment | x-ray diffraction | A | PP1 | 2 (best 0.69) |
| 5FM3 | Crystal structure of hyper-phosphorylated ret kinase domain with (proximal) juxtamembrane segment | x-ray diffraction | A | — | — |
| 6FEK | Oncogenic point mutation of RET receptor tyrosine kinase | x-ray diffraction | A | ADN | 2 (best 0.65) |
| 6FEK | Oncogenic point mutation of ret receptor tyrosine kinase | x-ray diffraction | A | ADN | — |
| 6GL7 | Neurturin-GFRa2-RET extracellular complex | electron microscopy | F, E | — | — |
| 6GL7 | Neurturin-GFRA2-ret extracellular complex | electron microscopy | F, E | — | — |
| 6I82 | Crystal structure of partially phosphorylated RET V804M tyrosine kinase domain complexed with… | x-ray diffraction | A, B | H6W, CL | 4 (best 0.81) |
| 6I82 | Crystal structure of partially phosphorylated ret V804M tyrosine kinase domain complexed with… | x-ray diffraction | A, B | H6W, CL | — |
| 6I83 | Crystal structure of phosphorylated RET V804M tyrosine kinase domain complexed with PDD00018366 | x-ray diffraction | A | H72 | — |
| 6I83 | Crystal structure of phosphorylated ret V804M tyrosine kinase domain complexed with PDD00018366 | x-ray diffraction | A | H72 | — |
| 6NE7 | Structure of G810A mutant of RET protein tyrosine kinase domain. | x-ray diffraction | A | AMP | 2 (best 0.57) |
| 6NE7 | Structure of G810A mutant of ret protein tyrosine kinase domain. | x-ray diffraction | A | AMP | — |
| 6NEC | Structure of ret protein tyrosine kinase domain in complex with nintedanib | x-ray diffraction | A, C | XIN | 4 (best 0.75) |
| 6NEC | Structure of ret protein tyrosine kinase domain in complex with nintedanib | x-ray diffraction | A, C | XIN | — |
| 6NJA | Structure of WT RET protein tyrosine kinase domain at 1.92A resolution. | x-ray diffraction | A | ADE | 2 (best 0.63) |
| 6NJA | Structure of wt ret protein tyrosine kinase domain at 1.92A resolution. | x-ray diffraction | A | ADE | — |
| 6Q2J | Cryo-EM structure of extracellular dimeric complex of RET/GFRAL/GDF15 | electron microscopy | E, F | NAG, CA | — |
| 6Q2N | Cryo-EM structure of RET/GFRa1/GDNF extracellular complex | electron microscopy | E, F | CA | 17 (best 0.77) |
| 6Q2N | Cryo-EM structure of RET/GFRA1/GDNF extracellular complex | electron microscopy | E, F | CA | — |
| 6Q2O | Cryo-EM structure of RET/GFRa2/NRTN extracellular complex. The 3D refinement was applied with C2… | electron microscopy | E, F | CA, NAG | 20 (best 0.85) |
| 6Q2O | Cryo-EM structure of RET/GFRA2/NRTN extracellular complex. the 3D refinement was applied with C2… | electron microscopy | E, F | CA, NAG | — |
| 6Q2R | Cryo-EM structure of RET/GFRA2/NRTN extracellular complex in the tetrameric form | electron microscopy | E, F, Y, Z | CA, NAG | — |
| 6Q2S | Cryo-EM structure of RET/GFRA3/ARTN extracellular complex. the 3D refinement was applied with C2… | electron microscopy | E, F | NAG, CA | — |
| 6VHG | Crystal structure of phosphorylated RET tyrosine kinase domain complexed with a… | x-ray diffraction | A | QX1, SO4, CL | — |
| 6VHG | Crystal structure of phosphorylated ret tyrosine kinase domain complexed with a… | x-ray diffraction | A | QX1, SO4, CL | — |
| 7DU8 | Crystal structure of human proto-oncogene tyrosine-protein kinase receptor ret in complex with… | x-ray diffraction | A, B | Q6G | — |
| 7DU9 | Crystal structure of human proto-oncogene tyrosine-protein kinase receptor ret in complex with… | x-ray diffraction | A, B | Q4J | — |
| 7DUA | Crystal structure of human Proto-oncogene tyrosine-protein kinase receptor Ret in complex with… | x-ray diffraction | A, B | HJ0 | — |
| 7DUA | Crystal structure of human proto-oncogene tyrosine-protein kinase receptor ret in complex with… | x-ray diffraction | A, B | HJ0 | — |
| 7JU5 | Structure of ret protein tyrosine kinase in complex with pralsetinib | x-ray diffraction | A, B | Q4J | — |
| 7JU6 | Structure of RET protein tyrosine kinase in complex with selpercatinib | x-ray diffraction | A, B | Q6G | 3 (best 0.82) |
| 7JU6 | Structure of ret protein tyrosine kinase in complex with selpercatinib | x-ray diffraction | A, B | Q6G | — |
| 7NZN | Structure of RET kinase domain bound to inhibitor JB-48 | x-ray diffraction | A | VJH | 2 (best 0.59) |
| 7NZN | Structure of ret kinase domain bound to inhibitor jb-48 | x-ray diffraction | A | VJH | — |
3 records more on the page itself.
Ligands
- CA · Calcium ion · in 7 records
- CL · Chloride ion · in 6 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 5 records
- Q6G · Selpercatinib · in 3 records
- 7QU · 1-(4-{(1s,3s)-3-[4-amino-5-(3-amino-4-chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl}piperazin-1-yl)ethan-1-one · in 2 records
- ADE · Adenine · in 2 records
- ADN · Adenosine · in 2 records
- AMP · Adenosine monophosphate · in 2 records
- H6W · ~{N}-[3-(1,3-benzodioxol-5-yl)pyrazolo[1,5-a]pyrimidin-5-yl]-~{N}',~{N}'-dimethyl-propane-1,3-diamine · in 2 records
- H72 · 4-[5-(pyridin-3-ylmethylamino)pyrazolo[1,5-a]pyrimidin-3-yl]benzamide · in 2 records
- HJ0 · 4-azanyl-7-(1-methylcyclopropyl)-~{N}-(5-methyl-1~{H}-pyrazol-3-yl)pyrrolo[2,3-d]pyrimidine-5-carboxamide · in 2 records
- PP1 · 1-ter-butyl-3-P-tolyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine · in 2 records
- Q4J · Pralsetinib · in 2 records
- QX1 · 3-(3,4-dimethoxyphenyl)-N~5~-(1-methylpiperidin-4-yl)-6-phenylpyrazolo[1,5-a]pyrimidine-5,7-diamine · in 2 records
- SO4 · Sulfate ion · in 2 records
- VJH · 2-[4-[[4-[1-[2-(dimethylamino)ethyl]pyrazol-4-yl]-6-[(3-methyl-1~{H}-pyrazol-5-yl)amino]pyrimidin-2-yl]amino]phenyl]-~{N}-(3-fluorophenyl)ethanamide · in 2 records
- XIN · Methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl) acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate · in 2 records
Elsewhere
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