MolNFT v1 · #40542 · protein
Crystal structure of phosphorylated ret tyrosine kinase domain complexed with the inhibitor ZD6474
2IVU · Proto-oncogene tyrosine-protein kinase receptor ret…: “Crystal structure of phosphorylated ret tyrosine kinase domain complexed with the inhibitor ZD6474”. X-ray diffraction, 1 ligand (ZD6), 2 pockets (best druggability 0.68).…
- PDB
- 2IVU
- Type
- protein
- Length
- 289 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proto-oncogene tyrosine-protein kinase receptor ret precursor
- EC
- 2.7.10.1
- UniProt
- P07949
- Ligands
- ZD6
- Pockets
- 2 · best druggability 0.68
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) | protein | 289 | 39% helix, 19% strand | P07949 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 344 | 0.68 | 0.82 | 42 | ZD6 |
| 2 | 80 | 0.31 | 0.73 | 18 | empty |
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 2IVU · Crystal structure of phosphorylated RET tyrosine kinase domain complexed with the… · the same entry in another collection · chain A against A, TM-score 1.00
- P07949 · AlphaFold monomer V2.0 prediction for proto-oncogene tyrosine-protein kinase receptor ret… · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07949
- Elsewhere: RCSB PDB 2IVU · PDBe 2IVU · UniProt P07949
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