MolNFT v1 · #167330 · protein
Crystal structure of phosphorylated ret tyrosine kinase domain complexed with a PYRAZOLO[1,5-A]PYRIMIDINE inhibitor
6VHG: “Crystal structure of phosphorylated ret tyrosine kinase domain complexed with a PYRAZOLO[1,5-A]PYRIMIDINE…”. X-ray diffraction, 3 ligands (QX1, SO4, CL). MolNFT v1 #167330 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 6VHG
- Type
- protein
- Length
- 283 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P07949
- Ligands
- QX1, SO4, CL
Structure
x-ray diffraction · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 283 | — | P07949 |
Ligands and binding sites
- QX1 · 3-(3,4-dimethoxyphenyl)-N~5~-(1-methylpiperidin-4-yl)-6-phenylpyrazolo[1,5-a]pyrimidine-5,7-diamine · ligand · chains A
- SO4 · Sulfate ion · ion · 4 copies · chains A
- CL · Chloride ion · ion · 2 copies · chains A
- ACT · Acetate ion · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6VHG · Crystal structure of phosphorylated RET tyrosine kinase domain complexed with a… · the same entry in another collection · chain A against A, TM-score 1.00
- P07949 · AlphaFold monomer V2.0 prediction for proto-oncogene tyrosine-protein kinase receptor ret… · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07949
- Elsewhere: RCSB PDB 6VHG · PDBe 6VHG · UniProt P07949
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