MolNFT v1 · #150152 · protein
Neurturin-GFRA2-ret extracellular complex
6GL7: “Neurturin-GFRA2-ret extracellular complex”. Electron microscopy, 20 pockets (best druggability 0.80). MolNFT v1 #150152 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6GL7
- Type
- protein
- Length
- 1,694 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Neurturin; Gdnf family receptor alpha-2; Proto-oncogene tyrosine-protein kinase receptor…
- EC
- 2.7.10.1
- UniProt
- Q99748, O00451, P07949
- Pockets
- 20 · best druggability 0.80
Structure
electron microscopy · 3 distinct chains · 27% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, A | Neurturin | protein | 100 | 14% helix, 38% strand | Q99748 |
| D, C | Gdnf family receptor alpha-2 | protein | 297 | 60% helix, 3% strand | O00451 |
| F, E | Proto-oncogene tyrosine-protein kinase receptor ret (EC 2.7.10.1) | protein | 450 | 8% helix, 34% strand | P07949 |
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 804 | 0.80 | 0.83 | 69 | empty |
| 2 | 755 | 0.79 | 0.83 | 60 | empty |
| 3 | 50 | 0.71 | 0.98 | 21 | empty |
| 4 | 219 | 0.71 | 0.87 | 31 | empty |
| 5 | 54 | 0.70 | 0.98 | 17 | empty |
Interfaces
5 interfaces between chains.
- B–A · 2087 Ų buried · 33 hydrogen bonds · protein-protein
- D–E · 988 Ų buried · 18 hydrogen bonds · protein-protein
- C–F · 909 Ų buried · 9 hydrogen bonds · protein-protein
- A–C · 852 Ų buried · 15 hydrogen bonds · protein-protein
- B–D · 837 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 43 disulfide (disulfide).
Compared structures
- 6GL7 · Neurturin-GFRa2-RET extracellular complex · the same entry in another collection · chain E against E, TM-score 1.00
- O00451 · AlphaFold monomer V2.0 prediction for gdnf family receptor alpha-2 (O00451) · a predicted model of the same protein · chain D against A, TM-score 0.95
- P07949 · AlphaFold monomer V2.0 prediction for proto-oncogene tyrosine-protein kinase receptor ret… · a predicted model of the same protein · chain F against A, TM-score 0.89
- Q99748 · AlphaFold monomer V2.0 prediction for neurturin (Q99748) · a predicted model of the same protein · chain B against A, TM-score 0.86
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99748
- Every structure of UniProt O00451
- Every structure of UniProt P07949
- Elsewhere: RCSB PDB 6GL7 · PDBe 6GL7 · UniProt Q99748 · UniProt O00451 · UniProt P07949
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