UniProt O00451
GDNF family receptor alpha-2 (O00451)
GDNF family receptor alpha-2 (UniProt O00451): 10 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 70 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O00451
- Protein
- GDNF family receptor alpha-2
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 70 · 4 records with a druggable one
Structures
11 records of O00451 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5MR4 | Ligand-receptor complex. | x-ray diffraction | C, D | — | 8 (best 0.47) |
| 5MR4 | Ligand-receptor complex. | x-ray diffraction | C, D | — | 8 (best 0.47) |
| 5MR5 | Ligand-receptor complex. | x-ray diffraction | C, D | SO4 | 4 (best 0.40) |
| 5MR5 | Ligand-receptor complex. | x-ray diffraction | C, D | SO4 | 4 (best 0.40) |
| 6GL7 | Neurturin-GFRa2-RET extracellular complex | electron microscopy | D, C | — | 12 (best 0.80) |
| 6GL7 | Neurturin-GFRA2-ret extracellular complex | electron microscopy | D, C | — | 12 (best 0.80) |
| 6Q2O | Cryo-EM structure of RET/GFRa2/NRTN extracellular complex. The 3D refinement was applied with C2… | electron microscopy | C, D | NAG | 9 (best 0.85) |
| 6Q2O | Cryo-EM structure of RET/GFRA2/NRTN extracellular complex. the 3D refinement was applied with C2… | electron microscopy | C, D | NAG | — |
| 6Q2R | Cryo-EM structure of RET/GFRa2/NRTN extracellular complex in the tetrameric form | electron microscopy | C, D, W, X | NAG | 13 (best 0.86) |
| 6Q2R | Cryo-EM structure of RET/GFRA2/NRTN extracellular complex in the tetrameric form | electron microscopy | C, D, W, X | NAG | — |
| O00451 | AlphaFold monomer V2.0 prediction for gdnf family receptor alpha-2 (O00451) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5MR5 chain C against the predicted model O00451: TM-score 0.99, RMSD 0.43 Å
- 5MR5 chain C against the predicted model O00451: TM-score 0.99, RMSD 0.43 Å
- 5MR5 chain D against the predicted model O00451: TM-score 0.99, RMSD 0.51 Å
- 5MR5 chain D against the predicted model O00451: TM-score 0.99, RMSD 0.51 Å
- 6Q2O chain C against the predicted model O00451: TM-score 0.98, RMSD 0.85 Å
- 6Q2O chain C against the predicted model O00451: TM-score 0.98, RMSD 0.85 Å
- 6Q2O chain D against the predicted model O00451: TM-score 0.98, RMSD 0.85 Å
- 6Q2O chain D against the predicted model O00451: TM-score 0.98, RMSD 0.85 Å
- 6Q2R chain X against the predicted model O00451: TM-score 0.98, RMSD 0.94 Å
- 6Q2R chain X against the predicted model O00451: TM-score 0.98, RMSD 0.94 Å
Elsewhere
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