UniProt P07293
Voltage-dependent L-type calcium channel subunit alpha-1S (P07293)
Voltage-dependent L-type calcium channel subunit alpha-1S (UniProt P07293): 34 experimental structures and 1 predicted model on GenesisL1, 15 ligands bound, 216 pockets. Binding sites, druggability and experiment against…
- UniProt
- P07293
- Protein
- Voltage-dependent L-type calcium channel subunit alpha-1S
- Experimental structures
- 34
- Predicted models
- 1
- Ligands
- 15
- Pockets
- 216 · 15 records with a druggable one
Structures
35 records of P07293 in the MolNFT archive: 34 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1DU1 | Peptide fragment THR671-LEU690 of the rabbit skeletal dihydropyridine receptor | solution nmr | A | — | — |
| 1DU1 | Peptide fragment THR671-LEU690 of the rabbit skeletal dihydropyridine receptor | solution nmr | A | — | — |
| 1T3L | Structural Analysis of the Voltage-Dependent Calcium Channel Beta Subunit Functional Core in… | x-ray diffraction | B | — | — |
| 1T3L | Structural analysis of the voltage-dependent calcium channel beta subunit functional core in… | x-ray diffraction | B | — | — |
| 3JBR | Cryo-EM structure of the rabbit voltage-gated calcium channel Cav1.1 complex at 4.2 angstrom | electron microscopy | A | CA | 13 (best 0.84) |
| 3JBR | Cryo-EM structure of the rabbit voltage-gated calcium channel CAV1.1 complex at 4.2 ångström | electron microscopy | A | — | — |
| 5GJV | Structure of the mammalian voltage-gated calcium channel Cav1.1 complex at near atomic resolution | electron microscopy | A | NAG, PC1, CA | 13 (best 0.82) |
| 5GJV | Structure of the mammalian voltage-gated calcium channel CAV1.1 complex at near atomic resolution | electron microscopy | A | — | — |
| 5GJW | Structure of the mammalian voltage-gated calcium channel CAV1.1 complex for classii MAP | electron microscopy | A | — | — |
| 6BYO | Residue assignment correction to the voltage gated calcium Cav1.1 rabbit alpha 1 subunit PDB… | electron microscopy | A | — | 19 (best 0.81) |
| 6BYO | Residue assignment correction to the voltage gated calcium CAV1.1 rabbit alpha 1 subunit pdb… | electron microscopy | A | — | — |
| 6JP5 | Rabbit Cav1.1-Nifedipine Complex | electron microscopy | A | NAG, CA, 3PE, C5U, PC1 | 15 (best 0.84) |
| 6JP5 | Rabbit CAV1.1-nifedipine complex | electron microscopy | A | NAG, CA, 3PE, C5U, PC1 | — |
| 6JP8 | Rabbit Cav1.1-Bay K8644 Complex | electron microscopy | A | C8U, NAG, CA | 15 (best 0.84) |
| 6JP8 | Rabbit CAV1.1-bay K8644 complex | electron microscopy | A | C8U, NAG, CA | — |
| 6JPA | Rabbit Cav1.1-Verapamil Complex | electron microscopy | A | NAG, CA, 3PE, PC1, 9Z9, 4YH | 14 (best 0.82) |
| 6JPA | Rabbit CAV1.1-verapamil complex | electron microscopy | A | NAG, CA, 3PE, PC1, 9Z9, 4YH | — |
| 6JPB | Rabbit Cav1.1-Diltiazem Complex | electron microscopy | A | NAG, CA, 3PE, PC1, C9F | 15 (best 0.84) |
| 6JPB | Rabbit CAV1.1-diltiazem complex | electron microscopy | A | NAG, CA, 3PE, PC1, C9F | — |
| 7JPK | Rabbit Cav1.1 in the presence of 100 micromolar (S)-(-)-Bay K8644 in nanodiscs at 3.0 Angstrom… | electron microscopy | A | CA, 3PE, PC1, C8U | 16 (best 0.84) |
| 7JPK | Rabbit CAV1.1 in the presence of 100 micromolar (S)-(-)-bay K8644 in nanodiscs at 3.0 ångström… | electron microscopy | A | CA, 3PE, PC1, C8U | — |
| 7JPL | Rabbit Cav1.1 in the presence of 10 micromolar (S)-(-)-Bay K8644 in nanodiscs at 3.4 Angstrom… | electron microscopy | A | CA, 3PE, PC1, C8U | 12 (best 0.85) |
| 7JPL | Rabbit CAV1.1 in the presence of 10 micromolar (S)-(-)-bay K8644 in nanodiscs at 3.4 ångström… | electron microscopy | A | CA, 3PE, PC1, C8U | — |
| 7JPV | Rabbit Cav1.1 in the presence of 1 micromolar (S)-(-)-Bay K8644 in nanodiscs at 3.4 Angstrom… | electron microscopy | A | CA, 3PE, PC1 | 14 (best 0.84) |
| 7JPV | Rabbit CAV1.1 in the presence of 1 micromolar (S)-(-)-bay K8644 in nanodiscs at 3.4 ångström… | electron microscopy | A | CA, 3PE, PC1 | — |
| 7JPW | Rabbit Cav1.1 in the presence of 100 micromolar (R)-(+)-Bay K8644 in nanodiscs at 3.2 Angstrom… | electron microscopy | A | CA, 3PE, PC1, VFY | 14 (best 0.84) |
| 7JPW | Rabbit CAV1.1 in the presence of 100 micromolar (R)-(+)-bay K8644 in nanodiscs at 3.2 ångström… | electron microscopy | A | CA, 3PE, PC1, VFY | — |
| 7JPX | Rabbit Cav1.1 in the presence of 100 micromolar amlodipine in nanodiscs at 2.9 Angstrom resolution | electron microscopy | A | CA, 3PE, PC1, POV, 6UB | 13 (best 0.86) |
| 7JPX | Rabbit CAV1.1 in the presence of 100 micromolar amlodipine in nanodiscs at 2.9 ångström resolution | electron microscopy | A | CA, 3PE, PC1, POV, 6UB | — |
| 7RXQ | Crystal structure of junctophilin-2 in complex with a CaV1.1 peptide | x-ray diffraction | B | SO4 | — |
| 7RXQ | Crystal structure of junctophilin-2 in complex with a CAV1.1 peptide | x-ray diffraction | B | — | — |
| 8E56 | Rabbit L-type voltage-gated calcium channel Cav1.1 in the presence of Amiodarone at 2.8 Angstrom… | electron microscopy | A | CA, BBI, 3PE | 15 (best 0.84) |
| 8E57 | Rabbit L-type voltage-gated calcium channel Cav1.1 in the presence of Amiodarone and 100 microM… | electron microscopy | A | CA, BBI, WFR | 14 (best 0.84) |
| 8E58 | Rabbit L-type voltage-gated calcium channel Cav1.1 in the presence of Amiodarone and 1 mM MNI-1 at… | electron microscopy | A | CA, BBI, WFR | 14 (best 0.84) |
| P07293 | AlphaFold monomer V2.0 prediction for voltage-dependent L-type calcium channel subunit alpha-1S… | predicted | A | — | — |
Ligands
- CA · Calcium ion · in 23 records
- 3PE · 1,2-diacyl-sn-glycero-3-phosphoethanolamine · in 17 records
- PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · in 17 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 9 records
- C8U · methyl (4~{S})-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate · in 6 records
- BBI · (2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone · in 3 records
- 4YH · (2S)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl) pentanenitrile · in 2 records
- 6UB · amlodipine · in 2 records
- 9Z9 · (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en · in 2 records
- C5U · dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate · in 2 records
- C9F · [(2~{S},3~{S})-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxidanylidene-2,3-dihydro-1,5-benzothiazepin-3-yl] ethanoate · in 2 records
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 2 records
- VFY · methyl (4~{R})-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate · in 2 records
- WFR · propan-2-yl (2S)-2-{[(S)-{[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-ethynyl-3-hydroxy-4-methyloxolan-2-yl]methoxy}(phenoxy)phosphoryl]amino}propanoate (non-preferred name) · in 2 records
- SO4 · Sulfate ion · in 1 record
Experiment against prediction
- 6JPA chain A against the predicted model P07293: TM-score 0.99, RMSD 1.31 Å
- 6JPA chain A against the predicted model P07293: TM-score 0.99, RMSD 1.31 Å
- 7JPX chain A against the predicted model P07293: TM-score 0.99, RMSD 1.24 Å
- 7JPX chain A against the predicted model P07293: TM-score 0.99, RMSD 1.24 Å
- 8E56 chain A against the predicted model P07293: TM-score 0.99, RMSD 1.25 Å
- 7JPK chain A against the predicted model P07293: TM-score 0.98, RMSD 1.34 Å
- 7JPK chain A against the predicted model P07293: TM-score 0.98, RMSD 1.34 Å
- 7JPV chain A against the predicted model P07293: TM-score 0.98, RMSD 1.35 Å
- 7JPV chain A against the predicted model P07293: TM-score 0.98, RMSD 1.35 Å
- 8E57 chain A against the predicted model P07293: TM-score 0.98, RMSD 1.35 Å
Elsewhere
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