Rabbit CAV1.1 in the presence of 100 micromolar (S)-(-)-bay K8644 in nanodiscs at 3.0 ångström resolution

Structure

electron microscopy · 3 distinct chains · 46% helix, 12% strand (DSSP).

Ligands and binding sites

• 3PE · 1,2-diacyl-sn-glycero-3-phosphoethanolamine · ligand · 9 copies · chains A, E
• PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · ligand · chains A
• C8U · methyl (4~{S})-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate · ligand · chains A
• CA · Calcium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Interfaces

2 interfaces between chains.

• A–F · 1896 Ų buried · 27 hydrogen bonds · protein-protein
• A–E · 1725 Ų buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 13 disulfide (disulfide).

Compared structures

• 7JPK · Rabbit Cav1.1 in the presence of 100 micromolar (S)-(-)-Bay K8644 in nanodiscs at 3.0… · the same entry in another collection · chain A against A, TM-score 1.00
• P13806 · AlphaFold monomer V2.0 prediction for voltage-dependent calcium channel subunit… · a predicted model of the same protein · chain F against A, TM-score 1.00
• P07293 · AlphaFold monomer V2.0 prediction for voltage-dependent L-type calcium channel subunit… · a predicted model of the same protein · chain A against A, TM-score 0.99
• P19518 · AlphaFold monomer V2.0 prediction for voltage-dependent calcium channel gamma-1 subunit… · a predicted model of the same protein · chain E against A, TM-score 0.89

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P07293
• Every structure of UniProt P19518
• Every structure of UniProt P13806
• Elsewhere: RCSB PDB 7JPK · PDBe 7JPK · UniProt P07293 · UniProt P19518 · UniProt P13806