UniProt P13806
Voltage-dependent calcium channel subunit alpha-2/delta-1 (P13806)
Voltage-dependent calcium channel subunit alpha-2/delta-1 (UniProt P13806): 24 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 74 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P13806
- Protein
- Voltage-dependent calcium channel subunit alpha-2/delta-1
- Experimental structures
- 24
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 74 · 9 records with a druggable one
Structures
25 records of P13806 in the MolNFT archive: 24 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3JBR | Cryo-EM structure of the rabbit voltage-gated calcium channel Cav1.1 complex at 4.2 angstrom | electron microscopy | F | — | — |
| 3JBR | Cryo-EM structure of the rabbit voltage-gated calcium channel CAV1.1 complex at 4.2 ångström | electron microscopy | F | — | — |
| 5GJV | Structure of the mammalian voltage-gated calcium channel Cav1.1 complex at near atomic resolution | electron microscopy | F | NAG, BMA, CA | 9 (best 0.81) |
| 5GJV | Structure of the mammalian voltage-gated calcium channel CAV1.1 complex at near atomic resolution | electron microscopy | F | — | — |
| 5GJW | Structure of the mammalian voltage-gated calcium channel CAV1.1 complex for classii MAP | electron microscopy | F | — | — |
| 6JP5 | Rabbit Cav1.1-Nifedipine Complex | electron microscopy | F | NAG, BMA, CA | — |
| 6JP5 | Rabbit CAV1.1-nifedipine complex | electron microscopy | F | NAG, BMA, CA, ETA | — |
| 6JP8 | Rabbit CAV1.1-bay K8644 complex | electron microscopy | F | NAG, BMA, ETA | — |
| 6JPA | Rabbit Cav1.1-Verapamil Complex | electron microscopy | F | NAG, BMA, CA | — |
| 6JPA | Rabbit CAV1.1-verapamil complex | electron microscopy | F | NAG, BMA, CA, ETA | — |
| 6JPB | Rabbit CAV1.1-diltiazem complex | electron microscopy | F | NAG, BMA, CA, ETA | — |
| 7JPK | Rabbit Cav1.1 in the presence of 100 micromolar (S)-(-)-Bay K8644 in nanodiscs at 3.0 Angstrom… | electron microscopy | F | — | 7 (best 0.80) |
| 7JPK | Rabbit CAV1.1 in the presence of 100 micromolar (S)-(-)-bay K8644 in nanodiscs at 3.0 ångström… | electron microscopy | F | — | — |
| 7JPL | Rabbit Cav1.1 in the presence of 10 micromolar (S)-(-)-Bay K8644 in nanodiscs at 3.4 Angstrom… | electron microscopy | F | — | 11 (best 0.83) |
| 7JPL | Rabbit CAV1.1 in the presence of 10 micromolar (S)-(-)-bay K8644 in nanodiscs at 3.4 ångström… | electron microscopy | F | — | — |
| 7JPV | Rabbit Cav1.1 in the presence of 1 micromolar (S)-(-)-Bay K8644 in nanodiscs at 3.4 Angstrom… | electron microscopy | F | — | 10 (best 0.81) |
| 7JPV | Rabbit CAV1.1 in the presence of 1 micromolar (S)-(-)-bay K8644 in nanodiscs at 3.4 ångström… | electron microscopy | F | — | — |
| 7JPW | Rabbit Cav1.1 in the presence of 100 micromolar (R)-(+)-Bay K8644 in nanodiscs at 3.2 Angstrom… | electron microscopy | F | — | 7 (best 0.84) |
| 7JPW | Rabbit CAV1.1 in the presence of 100 micromolar (R)-(+)-bay K8644 in nanodiscs at 3.2 ångström… | electron microscopy | F | — | — |
| 7JPX | Rabbit Cav1.1 in the presence of 100 micromolar amlodipine in nanodiscs at 2.9 Angstrom resolution | electron microscopy | F | — | 10 (best 0.80) |
| 7JPX | Rabbit CAV1.1 in the presence of 100 micromolar amlodipine in nanodiscs at 2.9 ångström resolution | electron microscopy | F | — | — |
| 8E57 | Rabbit L-type voltage-gated calcium channel Cav1.1 in the presence of Amiodarone and 100 microM… | electron microscopy | F | NAG, BMA, CA | 7 (best 0.80) |
| 8E58 | Rabbit L-type voltage-gated calcium channel Cav1.1 in the presence of Amiodarone and 1 mM MNI-1 at… | electron microscopy | F | NAG, BMA, CA | 7 (best 0.83) |
| 8EOG | Structure of the human L-type voltage-gated calcium channel Cav1.2 complexed with L-leucine | electron microscopy | D | NAG, CA, NA, LEU | 6 (best 0.83) |
| P13806 | AlphaFold monomer V2.0 prediction for voltage-dependent calcium channel subunit alpha-2/DELTA-1… | predicted | A | — | — |
Ligands
Experiment against prediction
- 6JPB chain F against the predicted model P13806: TM-score 1.00, RMSD 0.47 Å
- 6JP5 chain F against the predicted model P13806: TM-score 1.00, RMSD 0.47 Å
- 6JP8 chain F against the predicted model P13806: TM-score 1.00, RMSD 0.47 Å
- 6JP5 chain F against the predicted model P13806: TM-score 1.00, RMSD 0.47 Å
- 6JPA chain F against the predicted model P13806: TM-score 1.00, RMSD 0.47 Å
- 6JPA chain F against the predicted model P13806: TM-score 1.00, RMSD 0.48 Å
- 7JPW chain F against the predicted model P13806: TM-score 1.00, RMSD 0.59 Å
- 7JPW chain F against the predicted model P13806: TM-score 1.00, RMSD 0.59 Å
- 7JPK chain F against the predicted model P13806: TM-score 1.00, RMSD 0.61 Å
- 7JPK chain F against the predicted model P13806: TM-score 1.00, RMSD 0.61 Å
Elsewhere
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