Ligand · LEU
LEU · Leucine
LEU, Leucine (C6 H13 N O2, 131.2 g/mol), in the MolNFT structures on GenesisL1: bound in 26 records (26 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.
- Component
- LEU
- Formula
- C6 H13 N O2
- Class
- ligand
- Structures
- 26
- PDB entries
- 26
Binding sites
LEU in 26 structures; the first of them:
- 5ECN · Crystal Structure of FIN219-FIP1 complex with JA, Leu and ATP · LEU A602 · binds ALA165, THR166, VAL169, TYR170, VAL222, LYS530, ILE531, GLU533 and 1 more
- 5ECO · Crystal Structure of FIN219-FIP1 complex with JA, Leu and Mg · LEU A602 · binds THR164, ALA165, THR166, VAL169, TYR170, LYS530, GLU533, HIS534
- 5I92 · Crystal structure of Glutamate-1-semialdehyde 2,1- aminomutase (GSA) from Pseudomonas… · LEU F501 · binds ILE344, PHE359, ARG378, ARG381, PHE382, LEU385, ALA422, PHE423 and 2 more
- 5TGM · Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound… · LEU 13402 · binds C2405, A2808, U2954, U2955
- 5YTK · Crystal structure of SIRT3 bound to a leucylated AceCS2 · LEU B402 · binds PHE157, ARG158, PHE180, GLN228, ILE230, HIS248, ILE291, VAL292 and 1 more
- 6BV3 · Crystal structure of porcine aminopeptidase-N with Leucine · LEU A1024 · binds GLN206, GLN208, ALA346, ALA348, MET349, GLU350, HIS383, GLU384 and 3 more
- 6H2Q · Crystal Structure of Arg184Gln mutant of Human Prolidase with Mn ions and LeuPro ligand · LEU A506 · binds TYR241, ILE244, HIS255, ASP276, ASP287, HIS370, VAL376, HIS377 and 3 more
- 6KIE · Crystal structure of human leucyl-tRNA synthetase, Leu-AMS-bound form · LEU A1105 · binds ALA292, THR293, LEU294, ARG295, VAL389, THR390, SER396, ASP399 and 2 more
- 6NLE · X-ray structure of LeuT with V269 deletion · LEU A601 · binds ASN21, ALA22, GLY24, LEU25, GLY26, ASN27, VAL104, TYR108 and 6 more
- 6PY4 · Crystal structure of ligand-binding domain of Pseudomonas fluorescens chemoreceptor CtaA… · LEU A301 · binds ALA99, TYR101, ILE111, MET117, PHE121, ARG126, TRP128, TYR144 and 7 more
- 6S84 · TsaBDE complex from Thermotoga maritima · LEU B201 · binds ARG155, LYS156, GLU157
- 6W3S · Crystal structure of ligand-binding domain of Campylobacter jejuni chemoreceptor Tlp3 in… · LEU A301 · binds TYR118, VAL126, LEU128, LEU144, LYS149, TRP151, TYR167, LEU168 and 6 more
- 6YU6 · Crystal structure of MhsT in complex with L-leucine · LEU A503 · binds SER25, ALA26, GLY28, LEU29, GLY30, ASN31, ILE104, TYR108 and 8 more
- 7CMI · The LAT2-4F2hc complex in complex with leucine · LEU B601 · binds ASN52, ILE53, ILE54, GLY55, SER56, GLY57, ASN134, PHE243 and 5 more
- 7DJ2 · Crystal structure of the G26C/E290S mutant of LeuT · LEU A601 · binds ASN21, ALA22, VAL23, GLY24, LEU25, CYS26, ASN27, VAL104 and 8 more
- 7M32 · Dihydropyrimidine Dehydrogenase (DPD) C671A Mutant Soaked with Uracil and NADPH… · LEU B1101 · binds ASP579, ILE582, THR617, ARG1015, PRO1018
- 7NU5 · Crystal Structure of Neisseria gonorrhoeae LeuRS in Complex with L-leucine · LEU A1101 · binds MET40, PHE41, PRO42, TYR43, ASP80, SER510, TYR513, TYR541 and 2 more
- 7OEZ · Leucine Aminopeptidase A mature enzyme in a complex with leucine · LEU A414 · binds HIS176, ASP195, GLU233, GLU234, ASP261, MET262, TYR312, CYS314 and 6 more
- 7SR2 · Crystal structure of the human SNX25 regulator of G-protein signalling (RGS) domain · LEU B590 · binds LYS448, TYR561, GLU562, LYS563, LEU564
- 8AR7 · Bovine glutamate dehydrogenase in ternary complex with the allosteric activators ADP and… · LEU A603 · binds ASP241, GLN144, HIS145, VAL552, TYR553, ALA556, GLY557, VAL558 and 2 more
- 8EOG · Structure of the human L-type voltage-gated calcium channel Cav1.2 complexed with… · LEU D1108 · binds TRP207, TYR238, ARG243, TRP245, TYR452, ASP454, ALA455, LEU456 and 1 more
- 8FT4 · Multicrystal structure of Na+, leucine-bound LeuT determined at 5 keV · LEU A604 · binds ASN21, ALA22, GLY24, LEU25, GLY26, ASN27, VAL104, TYR108 and 6 more
Residues it binds most
TYR 33, PHE 20, VAL 27, ILE 24, GLY 17, ALA 25, ASP 20, THR 25, HIS 21, SER 14 (residue and the binding sites it lines).
Found with
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