UniProt P19518
Voltage-dependent calcium channel gamma-1 subunit (P19518)
Voltage-dependent calcium channel gamma-1 subunit (UniProt P19518): 26 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 30 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P19518
- Protein
- Voltage-dependent calcium channel gamma-1 subunit
- Experimental structures
- 26
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 30 · 11 records with a druggable one
Structures
27 records of P19518 in the MolNFT archive: 26 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3JBR | Cryo-EM structure of the rabbit voltage-gated calcium channel Cav1.1 complex at 4.2 angstrom | electron microscopy | E | — | — |
| 3JBR | Cryo-EM structure of the rabbit voltage-gated calcium channel CAV1.1 complex at 4.2 ångström | electron microscopy | E | — | — |
| 5GJV | Structure of the mammalian voltage-gated calcium channel Cav1.1 complex at near atomic resolution | electron microscopy | E | — | 2 (best 0.82) |
| 5GJV | Structure of the mammalian voltage-gated calcium channel CAV1.1 complex at near atomic resolution | electron microscopy | E | — | — |
| 5GJW | Structure of the mammalian voltage-gated calcium channel CAV1.1 complex for classii MAP | electron microscopy | E | — | — |
| 6JP5 | Rabbit Cav1.1-Nifedipine Complex | electron microscopy | E | 3PE, PC1 | — |
| 6JP5 | Rabbit CAV1.1-nifedipine complex | electron microscopy | E | 3PE, PC1 | — |
| 6JP8 | Rabbit Cav1.1-Bay K8644 Complex | electron microscopy | E | — | 3 (best 0.81) |
| 6JP8 | Rabbit CAV1.1-bay K8644 complex | electron microscopy | E | — | — |
| 6JPA | Rabbit Cav1.1-Verapamil Complex | electron microscopy | E | 3PE, PC1 | — |
| 6JPA | Rabbit CAV1.1-verapamil complex | electron microscopy | E | 3PE, PC1 | — |
| 6JPB | Rabbit Cav1.1-Diltiazem Complex | electron microscopy | E | 3PE, PC1 | 2 (best 0.81) |
| 6JPB | Rabbit CAV1.1-diltiazem complex | electron microscopy | E | 3PE | — |
| 7JPK | Rabbit Cav1.1 in the presence of 100 micromolar (S)-(-)-Bay K8644 in nanodiscs at 3.0 Angstrom… | electron microscopy | E | 3PE | 3 (best 0.77) |
| 7JPK | Rabbit CAV1.1 in the presence of 100 micromolar (S)-(-)-bay K8644 in nanodiscs at 3.0 ångström… | electron microscopy | E | 3PE | — |
| 7JPL | Rabbit Cav1.1 in the presence of 10 micromolar (S)-(-)-Bay K8644 in nanodiscs at 3.4 Angstrom… | electron microscopy | E | 3PE, PC1 | 3 (best 0.76) |
| 7JPL | Rabbit CAV1.1 in the presence of 10 micromolar (S)-(-)-bay K8644 in nanodiscs at 3.4 ångström… | electron microscopy | E | 3PE, PC1 | — |
| 7JPV | Rabbit Cav1.1 in the presence of 1 micromolar (S)-(-)-Bay K8644 in nanodiscs at 3.4 Angstrom… | electron microscopy | E | 3PE, PC1 | 2 (best 0.78) |
| 7JPV | Rabbit CAV1.1 in the presence of 1 micromolar (S)-(-)-bay K8644 in nanodiscs at 3.4 ångström… | electron microscopy | E | 3PE, PC1 | — |
| 7JPW | Rabbit Cav1.1 in the presence of 100 micromolar (R)-(+)-Bay K8644 in nanodiscs at 3.2 Angstrom… | electron microscopy | E | 3PE, PC1 | 5 (best 0.74) |
| 7JPW | Rabbit CAV1.1 in the presence of 100 micromolar (R)-(+)-bay K8644 in nanodiscs at 3.2 ångström… | electron microscopy | E | 3PE, PC1 | — |
| 7JPX | Rabbit Cav1.1 in the presence of 100 micromolar amlodipine in nanodiscs at 2.9 Angstrom resolution | electron microscopy | E | 3PE, PC1 | 2 (best 0.79) |
| 7JPX | Rabbit CAV1.1 in the presence of 100 micromolar amlodipine in nanodiscs at 2.9 ångström resolution | electron microscopy | E | 3PE, PC1 | — |
| 8E56 | Rabbit L-type voltage-gated calcium channel Cav1.1 in the presence of Amiodarone at 2.8 Angstrom… | electron microscopy | E | — | 2 (best 0.79) |
| 8E57 | Rabbit L-type voltage-gated calcium channel Cav1.1 in the presence of Amiodarone and 100 microM… | electron microscopy | E | — | 3 (best 0.79) |
| 8E58 | Rabbit L-type voltage-gated calcium channel Cav1.1 in the presence of Amiodarone and 1 mM MNI-1 at… | electron microscopy | E | — | 3 (best 0.72) |
| P19518 | AlphaFold monomer V2.0 prediction for voltage-dependent calcium channel gamma-1 subunit (P19518) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5GJW chain E against the predicted model P19518: TM-score 0.91, RMSD 2.08 Å
- 5GJV chain E against the predicted model P19518: TM-score 0.91, RMSD 2.16 Å
- 5GJV chain E against the predicted model P19518: TM-score 0.91, RMSD 2.16 Å
- 6JP5 chain E against the predicted model P19518: TM-score 0.89, RMSD 2.21 Å
- 6JP5 chain E against the predicted model P19518: TM-score 0.89, RMSD 2.21 Å
- 6JPA chain E against the predicted model P19518: TM-score 0.89, RMSD 2.34 Å
- 6JPA chain E against the predicted model P19518: TM-score 0.89, RMSD 2.34 Å
- 7JPW chain E against the predicted model P19518: TM-score 0.89, RMSD 2.23 Å
- 7JPW chain E against the predicted model P19518: TM-score 0.89, RMSD 2.23 Å
- 7JPL chain E against the predicted model P19518: TM-score 0.89, RMSD 2.22 Å
Elsewhere
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