MolNFT v1 · #178923 · protein
Rabbit CAV1.1 in the presence of 100 micromolar amlodipine in nanodiscs at 2.9 ångström resolution
7JPX: “Rabbit CAV1.1 in the presence of 100 micromolar amlodipine in nanodiscs at 2.9 ångström resolution”. Electron microscopy, 5 ligands (3PE, PC1, POV). MolNFT v1 #178923 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7JPX
- Type
- protein
- Length
- 2,258 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P07293, P19518, P13806
- Ligands
- 3PE, PC1, POV, 6UB, CA
Structure
electron microscopy · 3 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 1116 | — | P07293 |
| E | — | protein | 169 | — | P19518 |
| F | — | protein | 973 | — | P13806 |
Ligands and binding sites
- 3PE · 1,2-diacyl-sn-glycero-3-phosphoethanolamine · ligand · 9 copies · chains A, E
- PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · ligand · chains A, E
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · ligand · chains A
- 6UB · amlodipine · ligand · chains A
- CA · Calcium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7JPX · Rabbit Cav1.1 in the presence of 100 micromolar amlodipine in nanodiscs at 2.9 Angstrom… · the same entry in another collection · chain A against A, TM-score 1.00
- P13806 · AlphaFold monomer V2.0 prediction for voltage-dependent calcium channel subunit… · a predicted model of the same protein · chain F against A, TM-score 1.00
- P07293 · AlphaFold monomer V2.0 prediction for voltage-dependent L-type calcium channel subunit… · a predicted model of the same protein · chain A against A, TM-score 0.99
- P19518 · AlphaFold monomer V2.0 prediction for voltage-dependent calcium channel gamma-1 subunit… · a predicted model of the same protein · chain E against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07293
- Every structure of UniProt P19518
- Every structure of UniProt P13806
- Elsewhere: RCSB PDB 7JPX · PDBe 7JPX · UniProt P07293 · UniProt P19518 · UniProt P13806
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