MolNFT v1 · #22383 · protein
Structural analysis of the voltage-dependent calcium channel beta subunit functional core in complex with ALPHA1 interaction domain
1T3L · Dihydropyridine-sensitive L-type, calcium channel beta-2…: “Structural analysis of the voltage-dependent calcium channel beta subunit functional core in complex with…”. X-ray diffraction, 4 pockets (best druggability 0.44). MolNFT…
- PDB
- 1T3L
- Type
- protein
- Length
- 323 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dihydropyridine-sensitive L-type, calcium channel beta-2 subunit; Voltage-dependent…
- UniProt
- P54288, P07293
- Pockets
- 4 · best druggability 0.44
Structure
x-ray diffraction · 2 distinct chains · 46% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Dihydropyridine-sensitive L-type, calcium channel beta-2 subunit | protein | 306 | 44% helix, 18% strand | P54288 |
| B | Voltage-dependent L-type calcium channel alpha-1S subunit | protein | 17 | 82% helix, 0% strand | P07293 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 68 | 0.44 | 0.82 | 21 | empty |
| 2 | 79 | 0.36 | 0.77 | 16 | empty |
| 3 | 53 | 0.32 | 0.77 | 21 | empty |
| 4 | 57 | 0.30 | 0.75 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 868 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 1T3L · Structural Analysis of the Voltage-Dependent Calcium Channel Beta Subunit Functional Core… · the same entry in another collection · chain A against A, TM-score 1.00
- P54288 · AlphaFold monomer V2.0 prediction for voltage-dependent L-type calcium channel subunit… · a predicted model of the same protein · chain A against A, TM-score 0.95
- P07293 · AlphaFold monomer V2.0 prediction for voltage-dependent L-type calcium channel subunit… · a predicted model of the same protein · chain B against A, TM-score 0.72
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P54288
- Every structure of UniProt P07293
- Elsewhere: RCSB PDB 1T3L · PDBe 1T3L · UniProt P54288 · UniProt P07293
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