UniProt P01111
GTPase NRas (P01111)
GTPase NRas (UniProt P01111), EC 3.6.5.2: 37 experimental structures on GenesisL1, 8 ligands bound, 34 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P01111
- Protein
- GTPase NRas
- EC
- 3.6.5.2
- Experimental structures
- 37
- Predicted models
- 0
- Ligands
- 8
- Pockets
- 34 · 7 records with a druggable one
Structures
37 records of P01111 in the MolNFT archive: 37 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2N9C | NRAS Isoform 5 | solution nmr | A | — | — |
| 2N9C | NRAS isoform 5 | solution nmr | A | — | — |
| 3CON | Crystal structure of the human NRAS GTPase bound with GDP | x-ray diffraction | A | — | — |
| 3CON | Crystal structure of the human NRAS GTPase bound with GDP | x-ray diffraction | A | — | — |
| 5UHV | wild-type NRas bound to GppNHp | x-ray diffraction | A | GNP, MG | 1 (best 0.50) |
| 5UHV | Wild-type NRAS bound to gppnhp | x-ray diffraction | A | GNP, MG | — |
| 6E6H | NRAS G13D bound to GppNHp (N13GNP) | x-ray diffraction | A | MG, GNP | 1 (best 0.33) |
| 6E6H | NRAS G13D bound to gppnhp (N13GNP) | x-ray diffraction | A | MG, GNP | — |
| 6ULI | Molecular basis for tumor infiltrating TCR recognition of hotspot KRAS-G12D mutation | x-ray diffraction | C | — | — |
| 6ULI | Molecular basis for tumor infiltrating TCR recognition of hotspot KRAS-G12D mutation | x-ray diffraction | C | — | — |
| 6ULK | Molecular basis for tumor infiltrating TCR recognition of hotspot KRAS-G12D mutation | x-ray diffraction | C | — | — |
| 6ULK | Molecular basis for tumor infiltrating TCR recognition of hotspot KRAS-G12D mutation | x-ray diffraction | C | — | — |
| 6ULN | Molecular basis for tumor infiltrating TCR recognition of hotspot KRAS-G12D mutation | x-ray diffraction | C | — | — |
| 6ULN | Molecular basis for tumor infiltrating TCR recognition of hotspot KRAS-G12D mutation | x-ray diffraction | C | — | — |
| 6ULR | Molecular basis for tumor infiltrating TCR recognition of hotspot KRAS-G12D mutation | x-ray diffraction | C | — | — |
| 6UON | Molecular basis for tumor infiltrating TCR recognition of hotspot KRAS-G12D mutation | x-ray diffraction | C, F | — | — |
| 6WGH | Crystal structure of GDP-bound NRAS with ten residues long internal tandem duplication in the… | x-ray diffraction | A, B | GDP, MG | — |
| 6ZIO | Crystal structure of NRAS (C118S) in complex with GDP | x-ray diffraction | A, B | MG, GDP | 4 (best 0.47) |
| 6ZIO | Crystal structure of NRAS (C118S) in complex with GDP | x-ray diffraction | A, B | MG, GDP | — |
| 6ZIR | Crystal structure of NRAS (C118S) in complex with GDP and compound 18 | x-ray diffraction | A | MG, GDP, EZZ | 1 (best 0.43) |
| 6ZIR | Crystal structure of NRAS (C118S) in complex with GDP and compound 18 | x-ray diffraction | A | MG, GDP, EZZ | — |
| 6ZIZ | Crystal structure of NRAS Q61R in complex with GTP and compound 18 | x-ray diffraction | A, B | GTP, MG, EZZ | 3 (best 0.67) |
| 6ZIZ | Crystal structure of NRAS Q61R in complex with GTP and compound 18 | x-ray diffraction | A, B | GTP, MG, EZZ | — |
| 7F68 | Crystal structure of N-ras S89D | x-ray diffraction | A | GTP, MG, SO4 | 2 (best 0.54) |
| 7F68 | Crystal structure of N-RAS S89D | x-ray diffraction | A | GTP, MG, SO4 | — |
| 7OW3 | Crystal structure of HLA-A*11:01 in complex with KRAS peptide (vvvgaggvgk) | x-ray diffraction | C, F, I, L | — | — |
| 7OW4 | Crystal structure of HLA-A*11:01 in complex with KRAS G12D peptide (VVVGADGVGK) | x-ray diffraction | C, F, I, L | — | 1 (best 0.54) |
| 7OW4 | Crystal structure of HLA-A*11:01 in complex with KRAS G12D peptide (vvvgadgvgk) | x-ray diffraction | C, F, I, L | — | — |
| 7OW5 | Crystal structure of a TCR in complex with HLA-A*11:01 bound to KRAS peptide (VVVGAGGVGK) | x-ray diffraction | C | — | 2 (best 0.68) |
| 7OW5 | Crystal structure of a TCR in complex with HLA-A*11:01 bound to KRAS peptide (vvvgaggvgk) | x-ray diffraction | C | — | — |
| 7OW6 | Crystal structure of a TCR in complex with HLA-A*11:01 bound to KRAS G12D peptide (VVVGADGVGK) | x-ray diffraction | C | — | 3 (best 0.43) |
| 7OW6 | Crystal structure of a TCR in complex with HLA-A*11:01 bound to KRAS G12D peptide (vvvgadgvgk) | x-ray diffraction | C | — | — |
| 7PB2 | Crystal structure of JDI TCR in complex with HLA-A*11:01 bound to KRAS G12D peptide (VVVGADGVGK) | x-ray diffraction | C, H | — | 4 (best 0.56) |
| 7PB2 | Crystal structure of jdi TCR in complex with HLA-A*11:01 bound to KRAS G12D peptide (vvvgadgvgk) | x-ray diffraction | C, H | — | — |
| 8TBI | Tricomplex of RMC-7977, NRAS WT, and CypA | x-ray diffraction | A, B | GNP, MG, ZNI | 7 (best 0.80) |
| 8VM2 | Crystal Structure of NRAS Q61K bound to GTP | x-ray diffraction | A, B, C | GTP, MG, UNX | 5 (best 0.64) |
| P01111 | AlphaFold monomer V2.0 prediction for GTPase NRAS (P01111) | — | — | — |
Ligands
- MG · Magnesium ion · in 15 records
- GDP · Guanosine-5'-diphosphate · in 5 records
- GNP · Phosphoaminophosphonic acid-guanylate ester · in 5 records
- GTP · Guanosine-5'-triphosphate · in 5 records
- EZZ · (3~{S})-3-[2-[(dimethylamino)methyl]-1~{H}-indol-3-yl]-5-oxidanyl-2,3-dihydroisoindol-1-one · in 4 records
- SO4 · Sulfate ion · in 2 records
- UNX · Unknown atom or ion · in 1 record
- ZNI · (1R,5S,6r)-N-[(1P,7S,9S,13S,20M)-20-{5-(4-cyclopropylpiperazin-1-yl)-2-[(1S)-1-methoxyethyl]pyridin-3-yl}-21-ethyl-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,27,28-tetraazapentacyclo[17.5.2.1~2,5~.1~9,13~.0~22,26~]octacosa-1(24),2,5(28),19,22,25-hexaen-7-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide · in 1 record
Elsewhere
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