MolNFT v1 · #136073 · protein

Wild-type NRAS bound to gppnhp

5UHV · GTPase NRAS: “Wild-type NRAS bound to gppnhp”. X-ray diffraction, 2 ligands (GNP, MG), 1 pocket (best druggability 0.50). MolNFT v1 #136073 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5UHV
Type: protein
Length: 166 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: GTPase NRAS
UniProt: P01111
Ligands: GNP, MG
Pockets: 1 · best druggability 0.50

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	GTPase NRAS	protein	166	37% helix, 27% strand	P01111

Ligands and binding sites

GNP · Phosphoaminophosphonic acid-guanylate ester · ligand · chains A
MG · Magnesium ion · metal · chains A
GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	195	0.50	0.76	31	GNP, MG

Compared structures

5UHV · wild-type NRas bound to GppNHp · the same entry in another collection · chain A against A, TM-score 1.00
P01111 · AlphaFold monomer V2.0 prediction for GTPase NRAS (P01111) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01111
Elsewhere: RCSB PDB 5UHV · PDBe 5UHV · UniProt P01111

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.