ZNI · (1R,5S,6r)-N-[(1P,7S,9S,13S,20M)-20-{5-(4-cyclopropylpiperazin-1-yl)-2-[(1S)-1-methoxyethyl]pyridin-3-yl}-21-ethyl-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,27,28-tetraazapentacyclo[17.5.2.1~2,5~.1~9,13~.0~22,26~]octacosa-1(24),2,5(28),19,22,25-hexaen-7-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide

Binding sites

ZNI in 14 structures; the first of them:

• 8TBF · Tricomplex of RMC-7977, KRAS WT, and CypA · ZNI C202 · binds SER0, GLU3, ARG41, TYR32, PRO34, THR35, ILE36, ALA59 and 20 more
• 8TBG · Tricomplex of RMC-7977, HRAS WT, and CypA · ZNI C202 · binds GLY0, GLU3, ARG41, TYR32, PRO34, THR35, ILE36, GLU37 and 21 more
• 8TBH · Tricomplex of RMC-7977, KRAS G12R, and CypA · ZNI C201 · binds SER0, GLU3, ARG41, ARG12, TYR32, PRO34, THR35, ILE36 and 20 more
• 8TBI · Tricomplex of RMC-7977, NRAS WT, and CypA · ZNI C201 · binds SER0, GLU3, ARG41, TYR32, PRO34, THR35, ILE36, ALA59 and 20 more
• 8TBJ · Tricomplex of RMC-7977, KRAS G12A, and CypA · ZNI C202 · binds TYR32, PRO34, THR35, ILE36, GLU37, ALA59, GLN61, TYR64 and 18 more
• 8TBK · Tricomplex of RMC-7977, KRAS G12C, and CypA · ZNI C201 · binds SER0, GLU3, ARG41, TYR32, PRO34, THR35, ILE36, GLU37 and 21 more
• 8TBL · Tricomplex of RMC-7977, KRAS G12D, and CypA · ZNI C201 · binds TYR32, PRO34, THR35, ILE36, ALA59, GLN61, TYR64, MET67 and 17 more
• 8TBM · Tricomplex of RMC-7977, KRAS G12V, and CypA · ZNI D201 · binds TYR32, PRO34, THR35, ILE36, GLU37, ALA59, GLN61, TYR64 and 21 more
• 8TBN · Tricomplex of RMC-7977, KRAS G12S, and CypA · ZNI C201 · binds SER0, GLU3, ARG41, TYR32, PRO34, THR35, ILE36, ALA59 and 19 more
• 9BGH · Crystal structure of KRAS G12D in a transition state mimetic complex with CYPA and… · ZNI B201 · binds ARG55, ILE57, PHE60, MET61, GLN63, GLY72, THR73, ALA101 and 19 more
• 9BHO · Crystal structure of KRAS G12S in a transition state mimetic complex with CYPA and… · ZNI B201 · binds ARG55, ILE57, PHE60, MET61, GLN63, GLY72, THR73, ALA101 and 19 more
• 9BHP · Crystal structure of KRAS G12C in a transition state mimetic complex with CYPA and… · ZNI D201 · binds ARG55, ILE57, PHE60, MET61, GLN63, GLY72, THR73, ALA101 and 21 more
• 9BHQ · Crystal structure of KRAS G12A in a transition state mimetic complex with CYPA and… · ZNI B201 · binds ARG55, ILE57, PHE60, MET61, GLN63, GLY72, THR73, ALA101 and 20 more
• 9BI1 · Crystal structure of GMPPNP bound KRAS G12D in complex with CYPA and RMC-7977 · ZNI B201 · binds TYR32, PRO34, THR35, ILE36, ALA59, GLN61, TYR64, MET67 and 19 more

Residues it binds most

ALA 28, GLN 28, ARG 28, TYR 28, ILE 28, MET 28, PHE 28, GLU 27, THR 28, GLY 28 (residue and the binding sites it lines).

Found with

• MG · Magnesium ion
• GNP · Phosphoaminophosphonic acid-guanylate ester
• AF3 · Aluminum fluoride
• GDP · Guanosine-5'-diphosphate
• GOL · Glycerol
• EDO · 1,2-ethanediol