UniProt P00800
Thermolysin (P00800)
Thermolysin (UniProt P00800), EC 3.4.24.27: 387 experimental structures on GenesisL1, 46 ligands bound, 51 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P00800
- Protein
- Thermolysin
- EC
- 3.4.24.27
- Experimental structures
- 387
- Predicted models
- 0
- Ligands
- 46
- Pockets
- 51 · 4 records with a druggable one
Structures
387 records of P00800 in the MolNFT archive: 387 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1FJ3 | Thermolysin (50% acetone soaked) | x-ray diffraction | A | — | — |
| 1FJ3 | Thermolysin (50% acetone soaked) | x-ray diffraction | A | — | — |
| 1FJO | Thermolysin (60% acetone soaked crystals) | x-ray diffraction | A | — | — |
| 1FJO | Thermolysin (60% acetone soaked crystals) | x-ray diffraction | A | — | — |
| 1FJQ | Thermolysin (70% acetone soaked crystals) | x-ray diffraction | A | — | — |
| 1FJQ | Thermolysin (70% acetone soaked crystals) | x-ray diffraction | A | — | — |
| 1FJT | Thermolysin (50% acetonitrile soaked crystals) | x-ray diffraction | A | — | — |
| 1FJT | Thermolysin (50% acetonitrile soaked crystals) | x-ray diffraction | A | — | — |
| 1FJU | Thermolysin (80% acetonitrile soaked crystals) | x-ray diffraction | A | — | — |
| 1FJU | Thermolysin (80% acetonitrile soaked crystals) | x-ray diffraction | A | — | — |
| 1FJV | Thermolysin (60% acetonitrile soaked crystals) | x-ray diffraction | A | — | — |
| 1FJV | Thermolysin (60% acetonitrile soaked crystals) | x-ray diffraction | A | — | — |
| 1FJW | Thermolysin (50 mm phenol soaked) | x-ray diffraction | A | — | — |
| 1FJW | Thermolysin (50 mm phenol soaked) | x-ray diffraction | A | — | — |
| 1GXW | the 2.2 A resolution structure of thermolysin crystallized in presence of potassium thiocyanate | x-ray diffraction | A | — | — |
| 1GXW | The 2.2 a resolution structure of thermolysin crystallized in presence of potassium thiocyanate | x-ray diffraction | A | — | — |
| 1HYT | Re-determination and refinement of the complex of benzylsuccinic acid with thermolysin and its… | x-ray diffraction | A | — | — |
| 1HYT | Re-determination and refinement of the complex of benzylsuccinic acid with thermolysin and its… | x-ray diffraction | A | — | — |
| 1KEI | Thermolysin (substrate-free) | x-ray diffraction | A | — | — |
| 1KEI | Thermolysin (substrate-free) | x-ray diffraction | A | — | — |
| 1KJO | Thermolysin complexed with Z-L-Threonine (benzyloxycarbonyl-L-Threonine) | x-ray diffraction | A | — | — |
| 1KJO | Thermolysin complexed with Z-L-threonine (benzyloxycarbonyl-L- threonine) | x-ray diffraction | A | — | — |
| 1KJP | Thermolysin complexed with Z-L-Glutamic acid (benzyloxycarbonyl-L-Glutamic acid) | x-ray diffraction | A | — | — |
| 1KJP | Thermolysin complexed with Z-L-glutamic acid (benzyloxycarbonyl-L- glutamic acid) | x-ray diffraction | A | — | — |
| 1KKK | Thermolysin complexed with Z-L-Aspartic Acid (benzyloxycarbonyl-L-Aspartic Acid) | x-ray diffraction | A | — | — |
| 1KKK | Thermolysin complexed with Z-L-aspartic acid (benzyloxycarbonyl-L- aspartic acid) | x-ray diffraction | A | — | — |
| 1KL6 | Thermolysin complexed with Z-L-Alanine (benzyloxycarbonyl-L-Alanine) | x-ray diffraction | A | — | — |
| 1KL6 | Thermolysin complexed with Z-L-alanine (benzyloxycarbonyl-L-alanine) | x-ray diffraction | A | — | — |
| 1KR6 | Thermolysin complexed with Z-D-Glutamic acid (benzyloxycarbonyl-D-Glutamic acid) | x-ray diffraction | A | — | — |
| 1KR6 | Thermolysin complexed with Z-D-glutamic acid (benzyloxycarbonyl-D- glutamic acid) | x-ray diffraction | A | — | — |
| 1KRO | Thermolysin complexed with Z-D-Threonine (benzyloxycarbonyl-D-Threonine) | x-ray diffraction | A | — | — |
| 1KRO | Thermolysin complexed with Z-D-threonine (benzyloxycarbonyl-D- threonine) | x-ray diffraction | A | — | — |
| 1KS7 | Thermolysin complexed with Z-D-Aspartic acid (benzyloxycarbonyl-D-Aspartic acid) | x-ray diffraction | A | — | — |
| 1KS7 | Thermolysin complexed with Z-D-aspartic acid (benzyloxycarbonyl-D- aspartic acid) | x-ray diffraction | A | — | — |
| 1KTO | Thermolysin complexed with Z-D-Alanine (benzyloxycarbonyl-D-Alanine) | x-ray diffraction | A | — | — |
| 1KTO | Thermolysin complexed with Z-D-alanine (benzyloxycarbonyl-D-alanine) | x-ray diffraction | A | — | — |
| 1L3F | Thermolysin in the Absence of Substrate has an Open Conformation | x-ray diffraction | E | — | — |
| 1L3F | Thermolysin in the absence of substrate has an open conformation | x-ray diffraction | E | — | — |
| 1LNA | A structural analysis of metal substitutions in thermolysin | x-ray diffraction | E | — | — |
| 1LNA | A structural analysis of metal substitutions in thermolysin | x-ray diffraction | E | — | — |
| 1LNB | A structural analysis of metal substitutions in thermolysin | x-ray diffraction | E | — | — |
| 1LNB | A structural analysis of metal substitutions in thermolysin | x-ray diffraction | E | — | — |
| 1LNC | A structural analysis of metal substitutions in thermolysin | x-ray diffraction | E | — | — |
| 1LNC | A structural analysis of metal substitutions in thermolysin | x-ray diffraction | E | — | — |
| 1LND | A structural analysis of metal substitutions in thermolysin | x-ray diffraction | E | — | — |
| 1LND | A structural analysis of metal substitutions in thermolysin | x-ray diffraction | E | — | — |
| 1LNE | A structural analysis of metal substitutions in thermolysin | x-ray diffraction | E | — | — |
| 1LNE | A structural analysis of metal substitutions in thermolysin | x-ray diffraction | E | — | — |
| 1LNF | A structural analysis of metal substitutions in thermolysin | x-ray diffraction | E | — | — |
| 1LNF | A structural analysis of metal substitutions in thermolysin | x-ray diffraction | E | — | — |
| 1OS0 | Thermolysin with an alpha-amino phosphinic inhibitor | x-ray diffraction | A | — | — |
| 1OS0 | Thermolysin with an alpha-amino phosphinic inhibitor | x-ray diffraction | A | — | — |
| 1PE5 | Thermolysin with tricyclic inhibitor | x-ray diffraction | A | — | — |
| 1PE5 | Thermolysin with tricyclic inhibitor | x-ray diffraction | A | — | — |
| 1PE7 | Thermolysin with bicyclic inhibitor | x-ray diffraction | A | — | — |
| 1PE7 | Thermolysin with bicyclic inhibitor | x-ray diffraction | A | — | — |
| 1PE8 | Thermolysin with monocyclic inhibitor | x-ray diffraction | A | — | — |
| 1PE8 | Thermolysin with monocyclic inhibitor | x-ray diffraction | A | — | — |
| 1QF0 | Thermolysin (E.C.3.4.24.27) complexed with (2-sulphanyl-3-phenylpropanoyl)-phe-tyr. parameters for… | x-ray diffraction | A | — | — |
| 1QF0 | Thermolysin (E.C.3.4.24.27) complexed with (2-sulphanyl-3- phenylpropanoyl)-phe-tyr. parameters for… | x-ray diffraction | A | — | — |
327 records more on the page itself.
Ligands
- CA · Calcium ion · in 147 records
- ZN · Zinc ion · in 146 records
- XYP · beta-D-xylopyranose · in 19 records
- CL · Chloride ion · in 18 records
- 7GR · (2~{S})-4-methyl-2-[2-[[oxidanyl(phenylmethoxycarbonylaminomethyl) phosphoryl]amino]ethanoylamino]pentanoic acid · in 6 records
- PO4 · Phosphate ion · in 6 records
- NA · Sodium ion · in 5 records
- 6QC · ~{N}-[(2~{S})-1-[[(2~{R})-2,3-dimethylbutyl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]-(phenylmethoxycarbonylaminomethyl)phosphonamidic acid · in 4 records
- BCT · Bicarbonate ion · in 4 records
- KR · Krypton · in 4 records
- 6NG · N~2~-[(R)-({[(benzyloxy)carbonyl]amino}methyl) (hydroxy)phosphoryl]-N-[(2R)-2,3,3-trimethylbutyl]-L-leucinamide · in 3 records
- 45X · 2-(pyridin-3-yl)ethanamine · in 2 records
- 6MG · N~2~-[(R)-({[(benzyloxy)carbonyl]amino}methyl) (hydroxy)phosphoryl]-N-[(2S)-2,3,3-trimethylbutyl]-L-leucinamide · in 2 records
- 6XO · (2~{S})-3-cyclohexyl-2-[[(2~{S})-4-methyl-2-[[oxidanyl(phenylmethoxycarbonylaminomethyl) phosphoryl]amino]pentanoyl]amino]propanoic acid · in 2 records
- 79E · JC96 · in 2 records
- 79F · (2~{S})-4-methyl-2-[[(2~{S})-3-oxidanyl-2-[[oxidanyl(phenylmethoxycarbonylaminomethyl) phosphoryl]amino]propanoyl]amino]pentanoic acid · in 2 records
- 7AF · ~{N}-[(2~{S})-1-[[(2~{S})-2,3-dimethylbutyl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]-(phenylmethoxycarbonylaminomethyl)phosphonamidic acid · in 2 records
- 7K0 · (2~{S})-2-[[(2~{S})-3-azanyl-2-[[oxidanyl(phenylmethoxycarbonylaminomethyl) phosphoryl]amino]propanoyl]amino]-4-methyl-pentanoic acid · in 2 records
- 88B · 4-diazanyl-4-oxidanylidene-butanoic acid · in 2 records
- 8JH · ~{N}-[(2~{S})-1-(4-azanylbutylamino)-4-methyl-1-oxidanylidene-pentan-2-yl]-(phenylmethoxycarbonylaminomethyl)phosphonamidic acid · in 2 records
- 8JQ · ~{N}-[(2~{S})-1-(2-azanylethylamino)-4-methyl-1-oxidanylidene-pentan-2-yl]-(phenylmethoxycarbonylaminomethyl)phosphonamidic acid · in 2 records
- 8KK · ~{N}-[(2~{S})-1-(3-azanylpropylamino)-4-methyl-1-oxidanylidene-pentan-2-yl]-(phenylmethoxycarbonylaminomethyl)phosphonamidic acid · in 2 records
- 8KN · (2~{S})-5-azanyl-2-[[(2~{S})-4-methyl-2-[[oxidanyl(phenylmethoxycarbonylaminomethyl) phosphoryl]amino]pentanoyl]amino]pentanoic acid · in 2 records
- 8L2 · (2~{S})-3-azanyl-2-[[(2~{S})-4-methyl-2-[[oxidanyl(phenylmethoxycarbonylaminomethyl) phosphoryl]amino]pentanoyl]amino]propanoic acid · in 2 records
- 8L5 · ~{N}-[(2~{S})-1-(aminomethylamino)-4-methyl-1-oxidanylidene-pentan-2-yl]-(phenylmethoxycarbonylaminomethyl)phosphonamidic acid;hydrogen · in 2 records
- 8LB · (2~{S})-6-azanyl-2-[[(2~{S})-4-methyl-2-[[oxidanyl(phenylmethoxycarbonylaminomethyl) phosphoryl]amino]pentanoyl]amino]hexanoic acid · in 2 records
- AR · Argon · in 2 records
- INC · 2-(acetyl-hydroxy-amino)-4-methyl-pentanoic acid methyl ester · in 2 records
- JC2 · (2~{S})-4-azanyl-2-[[(2~{S})-4-methyl-2-[[oxidanyl(phenylmethoxycarbonylaminomethyl) phosphoryl]amino]pentanoyl]amino]butanoic acid · in 2 records
- L5Q · 5-methyl-~{N}-[2,2,2-tris(fluoranyl)ethyl]-1,2-oxazole-3-carboxamide · in 2 records
Elsewhere
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