UniProt O75762
Transient receptor potential cation channel subfamily A member 1 (O75762)
Transient receptor potential cation channel subfamily A member 1 (UniProt O75762): 28 experimental structures on GenesisL1, 13 ligands bound, 200 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- O75762
- Protein
- Transient receptor potential cation channel subfamily A member 1
- Experimental structures
- 28
- Predicted models
- 0
- Ligands
- 13
- Pockets
- 200 · 10 records with a druggable one
Structures
28 records of O75762 in the MolNFT archive: 28 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3J9P | Structure of the TRPA1 ion channel determined by electron cryo-microscopy | electron microscopy | D, A, B, C | — | — |
| 3J9P | Structure of the TRPA1 ion channel determined by electron cryo- microscopy | electron microscopy | D, A, B, C | — | — |
| 6HC8 | Factor Inhibiting HIF (FIH) in complex with zinc, NOG and TRPA1 (313-339) | x-ray diffraction | E | — | — |
| 6HC8 | Factor inhibiting hif (fih) in complex with zinc, nog and TRPA1 (313- 339) | x-ray diffraction | E | — | — |
| 6PQO | Cryo-EM structure of the human TRPA1 ion channel in complex with the covalent agonist JT010 | electron microscopy | D, A, B, C | NAG, JT0, LBN, 6OU | 20 (best 0.82) |
| 6PQO | Cryo-EM structure of the human TRPA1 ion channel in complex with the covalent agonist JT010 | electron microscopy | D, A, B, C | NAG, JT0, LBN, 6OU | — |
| 6PQP | Cryo-EM structure of the human TRPA1 ion channel in complex with the covalent agonist BITC | electron microscopy | A, D, B, C | NAG, 9BE, 6OU, LBN | 20 (best 0.83) |
| 6PQP | Cryo-EM structure of the human TRPA1 ion channel in complex with the covalent agonist bitc | electron microscopy | A, D, B, C | NAG, 9BE, 6OU, LBN | — |
| 6PQQ | Cryo-EM structure of human TRPA1 C621S mutant in the apo state | electron microscopy | A, B, D, C | LBN, 6OU | 20 (best 0.82) |
| 6PQQ | Cryo-EM structure of human TRPA1 C621S mutant in the apo state | electron microscopy | A, B, D, C | LBN, 6OU | — |
| 6V9V | Structure of TRPA1 modified by Bodipy-iodoacetamide with bound calcium, LMNG | electron microscopy | A, B, D, C | QT4, CA | 20 (best 0.83) |
| 6V9V | Structure of TRPA1 modified by bodipy-iodoacetamide with bound calcium, lmng | electron microscopy | A, B, D, C | QT4, CA | — |
| 6V9W | Structure of TRPA1 (ligand-free) with bound calcium, LMNG | electron microscopy | A, B, D, C | CA | 20 (best 0.83) |
| 6V9W | Structure of TRPA1 (ligand-free) with bound calcium, lmng | electron microscopy | A, B, D, C | CA | — |
| 6V9X | Structure of TRPA1 modified by iodoacetamide, PMAL-C8 | electron microscopy | A, B, D, C | — | 20 (best 0.76) |
| 6V9X | Structure of TRPA1 modified by iodoacetamide, pmal-C8 | electron microscopy | A, B, D, C | — | — |
| 6V9Y | Structure of TRPA1 bound with A-967079, PMAL-C8 | electron microscopy | A, B, D, C | — | 20 (best 0.81) |
| 6V9Y | Structure of TRPA1 bound with a-967079, pmal-C8 | electron microscopy | A, B, D, C | — | — |
| 6WJ5 | Structure of human TRPA1 in complex with inhibitor GDC-0334 | electron microscopy | A, B, C, D | LXY | 20 (best 0.86) |
| 6WJ5 | Structure of human TRPA1 in complex with inhibitor gdc-0334 | electron microscopy | A, B, C, D | LXY | — |
| 6X2J | Structure of human TRPA1 in complex with agonist GNE551 | electron microscopy | A, B, C, D | ULJ | — |
| 6X2J | Structure of human TRPA1 in complex with agonist GNE551 | electron microscopy | A, B, C, D | ULJ | — |
| 7JUP | Structure of human TRPA1 in complex with antagonist compound 21 | electron microscopy | A, B, C, D | VKM | 20 (best 0.85) |
| 7JUP | Structure of human TRPA1 in complex with antagonist compound 21 | electron microscopy | A, B, C, D | VKM | — |
| 7OR0 | Cryo-EM structure of the human TRPA1 ion channel in complex with the antagonist 3-60, conformation 2 | electron microscopy | A, B, C, D | NAG, 0IG, PC1, CA, IHP | 20 (best 0.84) |
| 7OR0 | Cryo-EM structure of the human TRPA1 ion channel in complex with the antagonist 3-60, conformation 2 | electron microscopy | A, B, C, D | NAG, 0IG, PC1, CA, IHP | — |
| 7OR1 | Cryo-EM structure of the human TRPA1 ion channel in complex with the antagonist 3-60, conformation 1 | electron microscopy | A, B, C, D | NAG, 0IG, PC1, CA, IHP | — |
| O75762 | AlphaFold monomer V2.0 prediction for transient receptor potential cation channel subfamily a… | — | — | — |
Ligands
- CA · Calcium ion · in 7 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 7 records
- 6OU · [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate · in 6 records
- LBN · 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine · in 6 records
- 0IG · ~{N}-[4-[4-[(azanylidene-$L^{4}-azanylidene) amino]phenyl]-1,3-thiazol-2-yl]-2-[1,3-dimethyl-2,6-bis(oxidanylidene)purin-7-yl]ethanamide · in 3 records
- IHP · Inositol hexakisphosphate · in 3 records
- PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · in 3 records
- 9BE · N-benzylthioformamide · in 2 records
- JT0 · 2-chloro-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-N-(3-methoxypropyl)acetamide · in 2 records
- LXY · (4R,5S)-4-fluoro-1-[(4-fluorophenyl)sulfonyl]-5-methyl-N-({5-(trifluoromethyl)-2-[2-(trifluoromethyl) pyrimidin-5-yl]pyridin-4-yl}methyl)-L-prolinamide · in 2 records
- QT4 · ~{N}-[[2,2-bis(fluoranyl)-10,12-dimethyl-1,3-diaza-2$l^{4}-boratricyclo[7.3.0.0^{3,7}]dodeca-4,6,9,11-tetraen-4-yl]methyl]ethanamide · in 2 records
- ULJ · 5-amino-1-[(4-bromo-2-fluorophenyl)methyl]-N-(2,5-dimethoxyphenyl)-1H-1,2,3-triazole-4-carboxamide · in 2 records
- VKM · 1-({3-[(3R,5R)-5-(4-fluorophenyl)oxolan-3-yl]-1,2,4-oxadiazol-5-yl}methyl)-7-methyl-1,7-dihydro-6H-purin-6-one · in 2 records
Experiment against prediction
- 3J9P chain D against the predicted model P0AEX9: TM-score 0.18, RMSD 5.89 Å
Elsewhere
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