MolNFT v1 · #184465 · protein
Cryo-EM structure of the human TRPA1 ion channel in complex with the antagonist 3-60, conformation 1
7OR1: “Cryo-EM structure of the human TRPA1 ion channel in complex with the antagonist 3-60, conformation 1”. Electron microscopy, 5 ligands (PC1, 0IG, IHP). MolNFT v1 #184465 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7OR1
- Type
- protein
- Length
- 2,384 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- O75762
- Ligands
- PC1, 0IG, IHP, NAG, CA
Structure
electron microscopy · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | — | protein | 596 | — | O75762 |
Ligands and binding sites
- PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · ligand · 8 copies · chains A, B, D, C
- 0IG · ~{N}-[4-[4-[(azanylidene-$L^{4}-azanylidene) amino]phenyl]-1,3-thiazol-2-yl]-2-[1,3-dimethyl-2,6-bis(oxidanylidene)purin-7-yl]ethanamide · ligand · 4 copies · chains A, B, C, D
- IHP · Inositol hexakisphosphate · ligand · 4 copies · chains A, B, C, D
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 12 copies · chains A, B, C, D
- CA · Calcium ion · metal · 5 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7OR1 · Cryo-EM structure of the human TRPA1 ion channel in complex with the antagonist 3-60… · the same entry in another collection · chain A against A, TM-score 1.00
- O75762 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain A against A, TM-score 0.86
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75762
- Elsewhere: RCSB PDB 7OR1 · PDBe 7OR1 · UniProt O75762
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