MolNFT v1 · #167073 · protein
Structure of TRPA1 modified by iodoacetamide, pmal-C8
6V9X · Transient receptor potential cation channel subfamily a…: “Structure of TRPA1 modified by iodoacetamide, pmal-C8”. Electron microscopy, 20 pockets (best druggability 0.76). MolNFT v1 #167073 on GenesisL1: 3D structure, binding sites…
- PDB
- 6V9X
- Type
- protein
- Length
- 2,284 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transient receptor potential cation channel subfamily a member 1
- UniProt
- O75762
- Pockets
- 20 · best druggability 0.76
Structure
electron microscopy · 1 distinct chain · 64% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, D, C | Transient receptor potential cation channel subfamily a member 1 | protein | 571 | 64% helix, 1% strand | O75762 |
Pockets
20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 426 | 0.76 | 0.84 | 42 | empty |
| 2 | 430 | 0.76 | 0.84 | 40 | empty |
| 3 | 408 | 0.76 | 0.84 | 39 | empty |
| 4 | 420 | 0.75 | 0.84 | 40 | empty |
| 5 | 677 | 0.74 | 0.80 | 69 | empty |
Interfaces
6 interfaces between chains.
- B–C · 3390 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 3388 Ų buried · 12 hydrogen bonds · protein-protein
- D–C · 3341 Ų buried · 9 hydrogen bonds · protein-protein
- A–D · 3341 Ų buried · 9 hydrogen bonds · protein-protein
- B–D · 445 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 modified (alkylation).
Compared structures
- 6V9X · Structure of TRPA1 modified by iodoacetamide, PMAL-C8 · the same entry in another collection · chain A against A, TM-score 1.00
- O75762 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain A against A, TM-score 0.85
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75762
- Elsewhere: RCSB PDB 6V9X · PDBe 6V9X · UniProt O75762
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