UniProt O15270
Serine palmitoyltransferase 2 (O15270)
Serine palmitoyltransferase 2 (UniProt O15270), EC 2.3.1.50: 30 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 210 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- O15270
- Protein
- Serine palmitoyltransferase 2
- EC
- 2.3.1.50
- Experimental structures
- 30
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 210 · 17 records with a druggable one
Structures
31 records of O15270 in the MolNFT archive: 30 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6M4N | Cryo-EM structure of the dimeric SPT-ORMDL3 complex | electron microscopy | B, F | PLP | 14 (best 0.88) |
| 6M4N | Cryo-EM structure of the dimeric spt-ORMDL3 complex | electron microscopy | B, F | PLP | — |
| 6M4O | Cryo-EM structure of the monomeric SPT-ORMDL3 complex | electron microscopy | T | PLP | 8 (best 0.85) |
| 6M4O | Cryo-EM structure of the monomeric spt-ORMDL3 complex | electron microscopy | T | PLP | — |
| 7CQI | Cryo-EM structure of the substrate-bound SPT-ORMDL3 complex | electron microscopy | T | PLS, GE0 | 11 (best 0.87) |
| 7CQI | Cryo-EM structure of the substrate-bound spt-ORMDL3 complex | electron microscopy | T | GE0 | — |
| 7CQK | Cryo-EM structure of the substrate-bound SPT-ORMDL3 complex | electron microscopy | T | PLS, GE0 | 14 (best 0.88) |
| 7CQK | Cryo-EM structure of the substrate-bound spt-ORMDL3 complex | electron microscopy | T | GE0 | — |
| 7K0I | Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa | electron microscopy | B, E | PLP, POV | 18 (best 0.84) |
| 7K0I | Human serine palmitoyltransferase complex SPTLC1/SPLTC2/SSSPTA | electron microscopy | B, E | PLP, POV | — |
| 7K0J | Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa protomer | electron microscopy | B | PLP, POV | 10 (best 0.84) |
| 7K0J | Human serine palmitoyltransferase complex SPTLC1/SPLTC2/SSSPTA protomer | electron microscopy | B | PLP | — |
| 7K0K | Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa, 3KS-bound | electron microscopy | B | PLP, VSD | 7 (best 0.82) |
| 7K0K | Human serine palmitoyltransferase complex SPTLC1/SPLTC2/SSSPTA, 3KS- bound | electron microscopy | B | PLP, VSD | — |
| 7K0L | Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa, myriocin-bound | electron microscopy | B | PLP, VRP | 9 (best 0.86) |
| 7K0L | Human serine palmitoyltransferase complex SPTLC1/SPLTC2/SSSPTA, myriocin-bound | electron microscopy | B | PLP, VRP | — |
| 7K0M | Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa/ORMDL3, class 1 | electron microscopy | B, F | PLP, POV | — |
| 7K0M | Human serine palmitoyltransferase complex SPTLC1/SPLTC2/SSSPTA/ORMDL3, class 1 | electron microscopy | B, F | PLP, POV | — |
| 7K0N | Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa/ORMDL3, class 2 | electron microscopy | B, F | PLP, POV | 17 (best 0.89) |
| 7K0N | Human serine palmitoyltransferase complex SPTLC1/SPLTC2/SSSPTA/ORMDL3, class 2 | electron microscopy | B, F | PLP, POV | — |
| 7K0O | Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa/ORMDL3, class 3 | electron microscopy | B, F | PLP, POV | 16 (best 0.87) |
| 7K0O | Human serine palmitoyltransferase complex SPTLC1/SPLTC2/SSSPTA/ORMDL3, class 3 | electron microscopy | B, F | PLP, POV | — |
| 7K0P | Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa/ORMDL3, class 4 | electron microscopy | B, F | PLP, POV | 16 (best 0.89) |
| 7K0P | Human serine palmitoyltransferase complex SPTLC1/SPLTC2/SSSPTA/ORMDL3, class 4 | electron microscopy | B, F | PLP, POV | — |
| 7K0Q | Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa/ORMDL3, myriocin-bound | electron microscopy | B | PLP, VRP | 10 (best 0.89) |
| 7K0Q | Human serine palmitoyltransferase complex SPTLC1/SPLTC2/SSSPTA/ORMDL3, myriocin-bound | electron microscopy | B | PLP, VRP | — |
| 7YIU | Cryo-EM structure of the C6-ceramide-bound SPT-ORMDL3 complex | electron microscopy | B | PLP, 6CM, R16 | 13 (best 0.89) |
| 7YIY | Cryo-EM structure of SPT-ORMDL3 complex | electron microscopy | B | PLP, Z1T | 14 (best 0.85) |
| 7YJ1 | Cryo-EM structure of SPT-ORMDL3 (ORMDL3-deltaN2) complex | electron microscopy | B | PLP | 10 (best 0.88) |
| 7YJ2 | Cryo-EM structure of SPT-ORMDL3 (ORMDL3-N13A) complex | electron microscopy | B | PLP | 13 (best 0.84) |
| O15270 | AlphaFold monomer V2.0 prediction for serine palmitoyltransferase 2 (O15270) | predicted | A | — | 10 (best 0.66) |
Ligands
- PLP · Pyridoxal-5'-phosphate · in 26 records
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 11 records
- GE0 · [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(3R)-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-4-[[3-oxidanylidene-3-[2-(2-oxidanylideneheptadecylsulfanyl) ethylamino]propyl]amino]butyl] hydrogen phosphate · in 4 records
- VRP · Myriocin · in 4 records
- PLS · [3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-ylmethyl]-serine · in 2 records
- VSD · 3-Dehydrosphinganine · in 2 records
- 6CM · N-((E,2S,3R)-1,3-dihydroxyoctadec-4-en-2-yl)hexanamide · in 1 record
- R16 · Hexadecane · in 1 record
- Z1T · N-[(2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl]tetracosanamide · in 1 record
Experiment against prediction
- 7K0K chain B against the predicted model O15270: TM-score 0.97, RMSD 1.43 Å
- 7K0K chain B against the predicted model O15270: TM-score 0.97, RMSD 1.43 Å
- 7K0J chain B against the predicted model O15270: TM-score 0.97, RMSD 1.48 Å
- 7K0J chain B against the predicted model O15270: TM-score 0.97, RMSD 1.48 Å
- 7K0I chain B against the predicted model O15270: TM-score 0.97, RMSD 1.50 Å
- 7K0I chain B against the predicted model O15270: TM-score 0.97, RMSD 1.50 Å
- 7K0N chain B against the predicted model O15270: TM-score 0.97, RMSD 1.53 Å
- 7K0N chain B against the predicted model O15270: TM-score 0.97, RMSD 1.53 Å
- 7K0M chain B against the predicted model O15270: TM-score 0.97, RMSD 1.56 Å
- 7K0M chain B against the predicted model O15270: TM-score 0.97, RMSD 1.56 Å
Elsewhere
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