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Ligand · PLS

PLS · [3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-ylmethyl]-serine

PLS, [3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-ylmethyl]-serine (C11 H17 N2 O8 P, 336.2 g/mol), in the MolNFT structures on GenesisL1: bound in 9 records (9 PDB entries). Every binding site with its residues within 4.5 Å, the…

Component
PLS
Formula
C11 H17 N2 O8 P
Class
ligand
Structures
9
PDB entries
9

Binding sites

PLS in 9 structures; the first of them:

  • 5DW0 · TrpB from Pyrococcus furiosus with L-serine bound as the external aldimine · PLS A401 · binds ALA80, HIS81, LYS82, GLU104, THR105, GLY106, ALA107, GLY108 and 21 more
  • 6AM9 · Engineered tryptophan synthase b-subunit from Pyrococcus furiosus, PfTrpB2B9, with… · PLS A403 · binds ALA80, HIS81, LYS82, GLU104, THR105, GLY106, ALA107, GLY108 and 21 more
  • 6SMW · A. thaliana serine hydroxymethyltransferase isoform 2 (AtSHMT2) in complex with pemetrexed · PLS A701 · binds SER82, SER148, GLY149, SER150, PRO151, ASN153, HIS177, SER179 and 15 more
  • 6YMF · Crystal structure of serine hydroxymethyltransferase from Aphanothece halophytica in the… · PLS A504 · binds SER36, SER98, GLY99, ALA100, ASN103, HIS127, THR129, HIS130 and 9 more
  • 7CQI · Cryo-EM structure of the substrate-bound SPT-ORMDL3 complex · PLS T601 · binds CYS133, PRO135, PHE337, SER338, ALA339, TYR176, GLY238, PHE239 and 11 more
  • 7XOY · Cystathionine beta-synthase of Mycobacterium tuberculosis in the presence of… · PLS B501 · binds LYS44, SER72, GLY73, ASN74, THR75, GLN147, GLY179, ILE180 and 11 more
  • 7YJO · Cryo-EM structure of the monomeric atSPT-ORM1 (LCB2a-deltaN5) complex · PLS B601 · binds PRO146, VAL343, PHE344, SER345, ALA346, TYR108, MET169, GLY170 and 13 more
  • 8B05 · TRYPTOPHAN SYNTHASE - Cryo-trapping by the spitrobot crystal plunger after 20 sec · PLS B402 · binds ALA85, HIS86, LYS87, THR110, GLY111, ALA112, GLY113, GLN114 and 20 more
  • 8IYP · Crystal structure of serine palmitoyltransferase soaked in 190 mM D-serine solution · PLS A401 · binds ASN52, THR112, GLY113, PHE114, ASN117, HIS138, SER140, ASP181 and 9 more

Residues it binds most

GLY 17, SER 17, HIS 16, ALA 13, THR 17, LYS 17, GLU 15, ASN 17, ASP 17, PRO 14 (residue and the binding sites it lines).

Found with

  • NA · Sodium ion
  • EDO · 1,2-ethanediol
  • 0JO · 2-{[(E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}prop-2-enoic acid
  • GE0 · [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(3R)-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-4-[[3-oxidanylidene-3-[2-(2-oxidanylideneheptadecylsulfanyl) ethylamino]propyl]amino]butyl] hydrogen phosphate
  • IND · Indole
  • LYA · 2-{4-[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-pentanedioic acid
  • PLP · Pyridoxal-5'-phosphate
  • SER · Serine
  • Z1T · N-[(2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl]tetracosanamide
  • CS · Cesium ion
  • CL · Chloride ion
  • 1PE · Pentaethylene glycol

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