GE0 · [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(3R)-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-4-[[3-oxidanylidene-3-[2-(2-oxidanylideneheptadecylsulfanyl) ethylamino]propyl]amino]butyl] hydrogen phosphate

Binding sites

GE0 in 3 structures; the first of them:

• 7CQI · Cryo-EM structure of the substrate-bound SPT-ORMDL3 complex · GE0 T602 · binds PRO135, PHE138, ARG181, ARG203, CYS336, PHE337, TYR122, LEU126 and 26 more
• 7CQI · Cryo-EM structure of the substrate-bound spt-ORMDL3 complex · GE0 T602 · binds PRO135, PHE138, ARG181, ARG203, CYS336, PHE337, TYR122, TYR127 and 21 more
• 7CQK · Cryo-EM structure of the substrate-bound spt-ORMDL3 complex · GE0 A201 · binds PRO135, PHE138, ARG203, CYS336, PHE337, TYR122, TYR127, TRP134 and 17 more

Residues it binds most

TYR 3, ARG 3, ILE 3, PRO 3, PHE 3, ASP 3, SER 3, VAL 3, ALA 2, ASN 3 (residue and the binding sites it lines).

Found with

• PLS · [3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-ylmethyl]-serine