MolNFT v2 · #183951 · protein

Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa/ORMDL3, class 1

7K0M: “Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa/ORMDL3, class 1”. Electron microscopy at 2.9, 2 ligands (POV, PLP). MolNFT v2 #183951 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7K0M
Type: protein
Length: 2,342 residues
Chains: 8
Method: electron microscopy
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.9
Source: Homo sapiens
UniProt: O15269, O15270, Q969W0, Q8N138
Ligands: POV, PLP

Structure

electron microscopy · resolution 2.9 · 4 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, E	—	protein	464	—	O15269
B, F	—	protein	492	—	O15270
C, G	—	protein	62	—	Q969W0
D, H	—	protein	153	—	Q8N138

Ligands and binding sites

POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · ligand · 14 copies · chains B, C, D, G, H, F
PLP · Pyridoxal-5'-phosphate · ligand · 2 copies · chains A, B, E, F

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7K0M · Human serine palmitoyltransferase complex SPTLC1/SPLTC2/SSSPTA/ORMDL3, class 1 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O15269
Every structure of UniProt O15270
Every structure of UniProt Q969W0
Every structure of UniProt Q8N138
Elsewhere: RCSB PDB 7K0M · PDBe 7K0M · UniProt O15269 · UniProt O15270 · UniProt Q969W0 · UniProt Q8N138

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