UniProt O15269
Serine palmitoyltransferase 1 (O15269)
Serine palmitoyltransferase 1 (UniProt O15269), EC 2.3.1.50: 19 experimental structures on GenesisL1, 4 ligands bound, 44 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- O15269
- Protein
- Serine palmitoyltransferase 1
- EC
- 2.3.1.50
- Experimental structures
- 19
- Predicted models
- 0
- Ligands
- 4
- Pockets
- 44 · 4 records with a druggable one
Structures
19 records of O15269 in the MolNFT archive: 19 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6M4N | Cryo-EM structure of the dimeric SPT-ORMDL3 complex | electron microscopy | A, E | PLP | 15 (best 0.88) |
| 6M4N | Cryo-EM structure of the dimeric spt-ORMDL3 complex | electron microscopy | A, E | PLP | — |
| 6M4O | Cryo-EM structure of the monomeric spt-ORMDL3 complex | electron microscopy | S, B | PLP | — |
| 7CQI | Cryo-EM structure of the substrate-bound spt-ORMDL3 complex | electron microscopy | S, C | GE0 | — |
| 7CQK | Cryo-EM structure of the substrate-bound spt-ORMDL3 complex | electron microscopy | S, C | GE0 | — |
| 7K0I | Human serine palmitoyltransferase complex SPTLC1/SPLTC2/SSSPTA | electron microscopy | A, D | PLP | — |
| 7K0J | Human serine palmitoyltransferase complex SPTLC1/SPLTC2/SSSPTA protomer | electron microscopy | A | PLP | — |
| 7K0K | Human serine palmitoyltransferase complex SPTLC1/SPLTC2/SSSPTA, 3KS- bound | electron microscopy | A | PLP, VSD | — |
| 7K0L | Human serine palmitoyltransferase complex SPTLC1/SPLTC2/SSSPTA, myriocin-bound | electron microscopy | A | PLP, VRP | — |
| 7K0M | Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa/ORMDL3, class 1 | electron microscopy | A, E | PLP | — |
| 7K0M | Human serine palmitoyltransferase complex SPTLC1/SPLTC2/SSSPTA/ORMDL3, class 1 | electron microscopy | A, E | PLP | — |
| 7K0N | Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa/ORMDL3, class 2 | electron microscopy | A, E | PLP | 11 (best 0.89) |
| 7K0N | Human serine palmitoyltransferase complex SPTLC1/SPLTC2/SSSPTA/ORMDL3, class 2 | electron microscopy | A, E | PLP | — |
| 7K0O | Human serine palmitoyltransferase complex SPTLC1/SPLTC2/SSSPTA/ORMDL3, class 3 | electron microscopy | A, E | PLP | — |
| 7K0P | Human serine palmitoyltransferase complex SPTLC1/SPLTC2/SSSPTA/ORMDL3, class 4 | electron microscopy | A, E | PLP | — |
| 7K0Q | Human serine palmitoyltransferase complex SPTLC1/SPLTC2/SSSPTA/ORMDL3, myriocin-bound | electron microscopy | A | PLP, VRP | — |
| 7YJ1 | Cryo-EM structure of SPT-ORMDL3 (ORMDL3-deltaN2) complex | electron microscopy | E, A | PLP | 7 (best 0.88) |
| 7YJ2 | Cryo-EM structure of SPT-ORMDL3 (ORMDL3-N13A) complex | electron microscopy | E, A | PLP | 11 (best 0.84) |
| O15269 | AlphaFold monomer V2.0 prediction for serine palmitoyltransferase 1 (O15269) | — | — | — |
Ligands
- PLP · Pyridoxal-5'-phosphate · in 16 records
- GE0 · [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(3R)-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-4-[[3-oxidanylidene-3-[2-(2-oxidanylideneheptadecylsulfanyl) ethylamino]propyl]amino]butyl] hydrogen phosphate · in 2 records
- VRP · Myriocin · in 2 records
- VSD · 3-dehydrosphinganine · in 1 record
Elsewhere
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