MolNFT v2 · #185996 · protein
Cryo-EM structure of full-length TRPV1 with capsaicin at 4 degrees Celsius
7LPA: “Cryo-EM structure of full-length TRPV1 with capsaicin at 4 degrees Celsius”. Electron microscopy at 3.37, 5 ligands (6OU, LBN, 4DY). MolNFT v2 #185996 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7LPA
- Type
- protein
- Length
- 2,392 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3.37
- Source
- Rattus norvegicus
- UniProt
- O35433
- Ligands
- 6OU, LBN, 4DY, YFP, NA
Structure
electron microscopy · resolution 3.37 · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | — | protein | 598 | — | O35433 |
Ligands and binding sites
- 6OU · [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate · ligand · 12 copies · chains A, D, B, C
- LBN · 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine · ligand · 8 copies · chains A, B, C, D
- 4DY · (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide · ligand · 4 copies · chains A, D, B, C
- YFP · 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol · ligand · 4 copies · chains A, D, B, C
- NA · Sodium ion · metal · 2 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7LPA · Cryo-EM structure of full-length TRPV1 with capsaicin at 4 degrees celsius · the same entry in another collection · chain A against A, TM-score 1.00
- O35433 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O35433
- Elsewhere: RCSB PDB 7LPA · PDBe 7LPA · UniProt O35433
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