MolNFT v1 · #478273 · protein
AlphaFold monomer V2.0 prediction for transient receptor potential cation channel subfamily V member 1 (O35433)
O35433: “AlphaFold monomer V2.0 prediction for transient receptor potential cation channel subfamily V member 1…”. 7 pockets (best druggability 0.66). MolNFT v1 #478273 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- O35433
- Type
- protein
- Length
- 838 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x3D1e520F55Fc226fbcf67321e6BBe1564494aac5
- Molecule
- Transient receptor potential cation channel subfamily V member 1
- UniProt
- O35433
- Pockets
- 7 · best druggability 0.66
Structure
1 distinct chain · 45% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transient receptor potential cation channel subfamily V member 1 | protein | 838 | 45% helix, 5% strand | O35433 |
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 376 | 0.66 | 0.80 | 42 | empty |
| 2 | 162 | 0.64 | 0.85 | 31 | empty |
| 3 | 117 | 0.64 | 0.87 | 21 | empty |
| 4 | 336 | 0.58 | 0.76 | 34 | empty |
| 5 | 104 | 0.43 | 0.78 | 18 | empty |
Compared structures
- 7LP9 · Cryo-EM structure of full-length TRPV1 at 4 degrees Celsius · an experimental structure of the same protein · chain A against B, TM-score 0.73
- 7LP9 · Cryo-EM structure of full-length TRPV1 at 4 degrees celsius · an experimental structure of the same protein · chain A against A, TM-score 0.73
- 7MZ9 · Cryo-EM structure of minimal TRPV1 with 1 partially bound rtx · an experimental structure of the same protein · chain A against C, TM-score 0.72
- 7MZ9 · Cryo-EM structure of minimal TRPV1 with 1 partially bound RTX · an experimental structure of the same protein · chain A against C, TM-score 0.72
- 7MZ6 · Cryo-EM structure of minimal TRPV1 with 1 perturbed PI · an experimental structure of the same protein · chain A against A, TM-score 0.72
- 7MZ6 · Cryo-EM structure of minimal TRPV1 with 1 perturbed pi · an experimental structure of the same protein · chain A against A, TM-score 0.72
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O35433
- Elsewhere: UniProt O35433 · AlphaFold DB O35433
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