MolNFT v1 · #189855 · protein
Cryo-EM structure of a monomeric GPCR-gi complex with small molecule
7W0M: “Cryo-EM structure of a monomeric GPCR-gi complex with small molecule”. Electron microscopy, 1 ligand (8EH). MolNFT v1 #189855 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7W0M
- Type
- protein
- Length
- 1,134 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P63096, P62873, P59768, P0ABE7, P35414
- Ligands
- 8EH
Structure
electron microscopy · 5 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 218 | — | P63096 |
| B | — | protein | 338 | — | P62873 |
| C | — | protein | 55 | — | P59768 |
| R | — | protein | 290 | — | P0ABE7, P35414 |
| S | — | protein | 233 | — | — |
Ligands and binding sites
- 8EH · (1R,2S)-N-[4-(2,6-dimethoxyphenyl)-5-(6-methylpyridin-2-yl)-1,2,4-triazol-3-yl]-1-(5-methylpyrimidin-2-yl)-1-oxidanyl-propane-2-sulfonamide · ligand · chains R
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7W0M · Cryo-EM structure of a monomeric GPCR-Gi complex with small molecule · the same entry in another collection · chain S against S, TM-score 1.00
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
- P35414 · AlphaFold monomer V2.0 prediction for apelin receptor (P35414) · a predicted model of the same protein · chain R against A, TM-score 0.88
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain C against A, TM-score 0.82
- P63096 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.81
- P0ABE7 · AlphaFold monomer V2.0 prediction for soluble cytochrome B562 (P0ABE7) · a predicted model of the same protein · chain R against A, TM-score 0.26
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63096
- Every structure of UniProt P62873
- Every structure of UniProt P59768
- Every structure of UniProt P0ABE7
- Every structure of UniProt P35414
- Elsewhere: RCSB PDB 7W0M · PDBe 7W0M · UniProt P63096 · UniProt P62873 · UniProt P59768 · UniProt P0ABE7 · UniProt P35414
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