UniProt P35414
Soluble cytochrome b562,Apelin receptor (P35414)
Soluble cytochrome b562,Apelin receptor (UniProt P35414): 21 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 38 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P35414
- Protein
- Soluble cytochrome b562,Apelin receptor
- Experimental structures
- 21
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 38 · 5 records with a druggable one
Structures
22 records of P35414 in the MolNFT archive: 21 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2LOT | AR55 solubilised in SDS micelles | solution nmr | A | — | — |
| 2LOT | AR55 solubilised in sds micelles | solution nmr | A | — | — |
| 2LOU | AR55 solubilised in DPC micelles | solution nmr | A | — | — |
| 2LOU | AR55 solubilised in dpc micelles | solution nmr | A | — | — |
| 2LOV | AR55 solubilised in LPPG micelles | solution nmr | A | — | — |
| 2LOV | AR55 solubilised in lppg micelles | solution nmr | A | — | — |
| 2LOW | Solution structure of AR55 in 50% HFIP | solution nmr | A | — | — |
| 2LOW | Solution structure of AR55 in 50% hfip | solution nmr | A | — | — |
| 5VBL | Structure of apelin receptor in complex with agonist peptide | x-ray diffraction | B | ZN | — |
| 6KNM | Apelin receptor in complex with single domain antibody | x-ray diffraction | B | ZN | — |
| 7SUS | Crystal structure of apelin receptor in complex with small molecule | x-ray diffraction | A | ZN, 8EH | — |
| 7W0L | Cryo-EM structure of a dimeric GPCR-Gi complex with small molecule | electron microscopy | Q, R | 8EH | 12 (best 0.77) |
| 7W0L | Cryo-EM structure of a dimeric GPCR-gi complex with small molecule | electron microscopy | Q, R | 8EH | — |
| 7W0M | Cryo-EM structure of a monomeric GPCR-gi complex with small molecule | electron microscopy | R | 8EH | — |
| 7W0N | Cryo-EM structure of a dimeric GPCR-gi complex with peptide | electron microscopy | Q, R | — | — |
| 7W0O | Cryo-EM structure of a monomeric GPCR-gi complex with peptide | electron microscopy | R | — | — |
| 7W0P | Cryo-EM structure of a GPCR-Gi complex with peptide | electron microscopy | R | — | 10 (best 0.82) |
| 7W0P | Cryo-EM structure of a GPCR-gi complex with peptide | electron microscopy | R | — | — |
| 8S4D | Crystal structure of a peptidergic GPCR in complex with a small synthetic G protein-biased agonist | x-ray diffraction | A | A1D5N, OLA | 4 (best 0.79) |
| 8XZH | Cryo-EM structure of the MM07-bound human APLNR-Gi complex | electron microscopy | R | — | 7 (best 0.70) |
| 8XZJ | Cryo-EM structure of the WN353-bound human APLNR-Gi complex | electron microscopy | R | — | 5 (best 0.68) |
| P35414 | AlphaFold monomer V2.0 prediction for apelin receptor (P35414) | predicted | A | — | — |
Ligands
- 8EH · (1R,2S)-N-[4-(2,6-dimethoxyphenyl)-5-(6-methylpyridin-2-yl)-1,2,4-triazol-3-yl]-1-(5-methylpyrimidin-2-yl)-1-oxidanyl-propane-2-sulfonamide · in 4 records
- ZN · Zinc ion · in 3 records
- A1D5N · (3~{S})-5-methyl-3-[[1-pentan-3-yl-2-(thiophen-2-ylmethyl)benzimidazol-5-yl]carbonylamino]hexanoic acid · in 1 record
- OLA · Oleic acid · in 1 record
Experiment against prediction
- 5VBL chain B against the predicted model P00268: TM-score 0.15, RMSD 0.38 Å
- 7SUS chain A against the predicted model P00268: TM-score 0.16, RMSD 0.41 Å
- 6KNM chain B against the predicted model P00268: TM-score 0.15, RMSD 0.52 Å
- 8XZH chain R against the predicted model P35414: TM-score 0.90, RMSD 2.71 Å
- 8XZJ chain R against the predicted model P35414: TM-score 0.89, RMSD 2.69 Å
- 7W0L chain R against the predicted model P35414: TM-score 0.89, RMSD 2.85 Å
- 7W0L chain R against the predicted model P35414: TM-score 0.89, RMSD 2.85 Å
- 7W0N chain R against the predicted model P35414: TM-score 0.88, RMSD 3.05 Å
- 7W0M chain R against the predicted model P35414: TM-score 0.88, RMSD 2.96 Å
- 7W0P chain R against the predicted model P35414: TM-score 0.87, RMSD 2.97 Å
Elsewhere
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