Crystal structure of apelin receptor in complex with small molecule

Structure

x-ray diffraction · 1 distinct chain.

Ligands and binding sites

• 8EH · (1R,2S)-N-[4-(2,6-dimethoxyphenyl)-5-(6-methylpyridin-2-yl)-1,2,4-triazol-3-yl]-1-(5-methylpyrimidin-2-yl)-1-oxidanyl-propane-2-sulfonamide · ligand · chains A
• ZN · Zinc ion · metal · chains A
• OLC · (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7SUS · Crystal structure of Apelin receptor in complex with small molecule · the same entry in another collection · chain A against A, TM-score 1.00
• P35414 · AlphaFold monomer V2.0 prediction for apelin receptor (P35414) · a predicted model of the same protein · chain A against A, TM-score 0.83
• P00268 · AlphaFold monomer V2.0 prediction for rubredoxin (P00268) · a predicted model of the same protein · chain A against A, TM-score 0.16

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P35414
• Every structure of UniProt P00268
• Elsewhere: RCSB PDB 7SUS · PDBe 7SUS · UniProt P35414 · UniProt P00268