MolNFT v1 · #187892 · protein

Cryoem structure of somatostatin receptor 2 in complex with somatostatin-14 and GI3

7T10 · Somatostatin receptor type 2,KAPPA-type opioid receptor: “Cryoem structure of somatostatin receptor 2 in complex with somatostatin-14 and GI3”. Electron microscopy, 14 pockets (best druggability 0.82). MolNFT v1 #187892 on…

PDB: 7T10
Type: protein
Length: 1,146 residues
Chains: 6
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Somatostatin receptor type 2,KAPPA-type opioid receptor; Guanine nucleotide-binding…
UniProt: P30874, P41145, P08754, P62873, P59768, P61278
Pockets: 14 · best druggability 0.82

Structure

electron microscopy · 6 distinct chains · 34% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
R	Somatostatin receptor type 2,KAPPA-type opioid receptor	protein	287	77% helix, 3% strand	P30874, P41145
A	Guanine nucleotide-binding protein G(I) subunit alpha-3	protein	218	47% helix, 18% strand	P08754
B	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	protein	338	8% helix, 47% strand	P62873
C	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	protein	57	61% helix, 0% strand	P59768
P	Somatostatin-14	protein	14	0% helix, 29% strand	P61278
S	SCFV16	protein	232	4% helix, 46% strand	—

Pockets

14 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	977	0.82	0.83	63	empty
2	55	0.68	0.96	19	empty
3	675	0.68	0.76	59	empty
4	297	0.59	0.78	43	empty
5	235	0.59	0.79	30	empty

Interfaces

6 interfaces between chains.

B–C · 2052 Å² buried · 6 hydrogen bonds · protein-protein
R–P · 1165 Å² buried · 6 hydrogen bonds · protein-protein
A–B · 1026 Å² buried · 7 hydrogen bonds · protein-protein
R–A · 990 Å² buried · 1 hydrogen bond · protein-protein
A–S · 525 Å² buried · 2 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

7T10 · CryoEM structure of somatostatin receptor 2 in complex with somatostatin-14 and Gi3 · the same entry in another collection · chain S against S, TM-score 1.00
P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
P30874 · AlphaFold monomer V2.0 prediction for somatostatin receptor type 2 (P30874) · a predicted model of the same protein · chain R against A, TM-score 0.88
P41145 · AlphaFold monomer V2.0 prediction for kappa-type opioid receptor (P41145) · a predicted model of the same protein · chain R against A, TM-score 0.86
P08754 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.81
P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain C against A, TM-score 0.80
P61278 · AlphaFold monomer V2.0 prediction for somatostatin (P61278) · a predicted model of the same protein · chain P against A, TM-score 0.28

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P30874
Every structure of UniProt P41145
Every structure of UniProt P08754
Every structure of UniProt P62873
Every structure of UniProt P59768
Every structure of UniProt P61278
Elsewhere: RCSB PDB 7T10 · PDBe 7T10 · UniProt P30874 · UniProt P41145 · UniProt P08754 · UniProt P62873 · UniProt P59768 · UniProt P61278

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.