UniProt P41145
Kappa-type opioid receptor (P41145)
Kappa-type opioid receptor (UniProt P41145): 21 experimental structures and 1 predicted model on GenesisL1, 14 ligands bound, 49 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P41145
- Protein
- Kappa-type opioid receptor
- Experimental structures
- 21
- Predicted models
- 1
- Ligands
- 14
- Pockets
- 49 · 11 records with a druggable one
Structures
22 records of P41145 in the MolNFT archive: 21 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4DJH | Structure of the human kappa opioid receptor in complex with JDTic | x-ray diffraction | A, B | — | — |
| 4DJH | Structure of the human kappa opioid receptor in complex with jdtic | x-ray diffraction | A, B | — | — |
| 6B73 | Crystal structure of a nanobody-stabilized active state of the kappa- opioid receptor | x-ray diffraction | A, B | CVV, CLR, OLA | — |
| 6VI4 | Nanobody-Enabled Monitoring of Kappa Opioid Receptor States | x-ray diffraction | A, B | JDC, CLR | — |
| 6VI4 | Nanobody-enabled monitoring of kappa opioid receptor states | x-ray diffraction | A, B | JDC, CLR | — |
| 7T10 | CryoEM structure of somatostatin receptor 2 in complex with somatostatin-14 and Gi3 | electron microscopy | R | — | 8 (best 0.68) |
| 7T10 | Cryoem structure of somatostatin receptor 2 in complex with somatostatin-14 and GI3 | electron microscopy | R | — | — |
| 7T11 | CryoEM structure of somatostatin receptor 2 in complex with Octreotide and Gi3. | electron microscopy | R | — | 5 (best 0.64) |
| 7T11 | Cryoem structure of somatostatin receptor 2 in complex with octreotide and GI3. | electron microscopy | R | — | — |
| 7UL2 | CryoEM Structure of Inactive NTSR1 Bound to SR48692 and Nb6 | electron microscopy | R | Q6Q, NA | — |
| 7UL2 | Cryoem structure of inactive NTSR1 bound to SR48692 and NB6 | electron microscopy | R | Q6Q, NA | — |
| 7UL5 | CryoEM Structure of Inactive SSTR2 bound to Nb6 | electron microscopy | A | — | — |
| 7UL5 | Cryoem structure of inactive SSTR2 bound to NB6 | electron microscopy | A | — | — |
| 7YIT | Molecular mechanism of biased signaling at the kappa opioid receptor | x-ray diffraction | A | IVB | 4 (best 0.76) |
| 8DZP | momSalB bound Kappa Opioid Receptor in complex with Gi1 | electron microscopy | A | U99 | 3 (best 0.79) |
| 8DZR | GR89,696 bound Kappa Opioid Receptor in complex with gustducin | electron microscopy | A | U9I | 3 (best 0.76) |
| 8DZS | GR89,696 bound Kappa Opioid Receptor in complex with Gz | electron microscopy | A | U9I | 3 (best 0.76) |
| 8F7W | Gi bound kappa-opioid receptor in complex with dynorphin | electron microscopy | R | CLR, PLM | 4 (best 0.66) |
| 8FEG | CryoEM structure of Kappa Opioid Receptor bound to a semi-peptide and Gi1 | electron microscopy | B | — | 3 (best 0.80) |
| 8HNN | Structure of CXCR3 complexed with antagonist SCH546738 | electron microscopy | R | 43I, CLR | 5 (best 0.67) |
| 8K2W | Structure of CXCR3 complexed with antagonist AMG487 | electron microscopy | R | CLR, PCW, LPC, FI6 | 5 (best 0.71) |
| P41145 | AlphaFold monomer V2.0 prediction for kappa-type opioid receptor (P41145) | predicted | A | — | 6 (best 0.84) |
Ligands
- CLR · Cholesterol · in 6 records
- JDC · (3R)-7-hydroxy-N-{(2S)-1-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl}-1,2,3, 4-tetrahydroisoquinoline-3-carboxamide · in 2 records
- NA · Sodium ion · in 2 records
- Q6Q · 2-[[1-(7-chloranylquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl]carbonylamino]adamantane-2-carboxylic acid · in 2 records
- U9I · methyl (3R)-4-[(3,4-dichlorophenyl)acetyl]-3-[(pyrrolidin-1-yl)methyl]piperazine-1-carboxylate · in 2 records
- 43I · 3-azanyl-6-chloranyl-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-3-ethyl-piperazin-1-yl]pyrazine-2-carboxamide · in 1 record
- CVV · N-[(5alpha,6beta)-17-(cyclopropylmethyl)-3-hydroxy-7,8-didehydro-4,5-epoxymorphinan-6-yl]-3-iodobenzamide · in 1 record
- FI6 · N-[(1R)-1-[3-(4-ethoxyphenyl)-4-oxidanylidene-pyrido[2,3-d]pyrimidin-2-yl]ethyl]-N-(pyridin-3-ylmethyl)-2-[4-(trifluoromethyloxy)phenyl]ethanamide · in 1 record
- IVB · nalfurafine · in 1 record
- LPC · [1-myristoyl-glycerol-3-yl]phosphonylcholine · in 1 record
- OLA · Oleic acid · in 1 record
- PCW · 1,2-dioleoyl-sn-glycero-3-phosphocholine · in 1 record
- PLM · Palmitic acid · in 1 record
- U99 · methyl (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(furan-3-yl)-9-(methoxymethoxy)-6a,10b-dimethyl-4,10-dioxododecahydro-2H-naphtho[2,1-c]pyran-7-carboxylate · in 1 record
Experiment against prediction
- 6VI4 chain B against the predicted model P41145: TM-score 0.97, RMSD 1.26 Å
- 6VI4 chain B against the predicted model P41145: TM-score 0.97, RMSD 1.26 Å
- 6VI4 chain A against the predicted model P41145: TM-score 0.97, RMSD 1.40 Å
- 6VI4 chain A against the predicted model P41145: TM-score 0.97, RMSD 1.40 Å
- 7UL5 chain A against the predicted model P41145: TM-score 0.93, RMSD 1.99 Å
- 7UL5 chain A against the predicted model P41145: TM-score 0.93, RMSD 1.99 Å
- 8K2W chain R against the predicted model P49682: TM-score 0.91, RMSD 1.83 Å
- 8F7W chain R against the predicted model P41145: TM-score 0.90, RMSD 2.60 Å
- 6B73 chain A against the predicted model P41145: TM-score 0.90, RMSD 2.50 Å
- 6B73 chain B against the predicted model P41145: TM-score 0.90, RMSD 2.48 Å
Elsewhere
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