MolNFT v1 · #188899 · protein
Cryoem structure of inactive SSTR2 bound to NB6
7UL5 · Somatostatin receptor type 2: “Cryoem structure of inactive SSTR2 bound to NB6”. Electron microscopy, 3 pockets (best druggability 0.70). MolNFT v1 #188899 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7UL5
- Type
- protein
- Length
- 371 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Somatostatin receptor type 2; Nanobody 6
- UniProt
- P30874, P41145
- Pockets
- 3 · best druggability 0.70
Structure
electron microscopy · 2 distinct chains · 61% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Somatostatin receptor type 2 | protein | 285 | 79% helix, 4% strand | P30874, P41145 |
| D | Nanobody 6 | protein | 86 | 0% helix, 49% strand | — |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 574 | 0.70 | 0.78 | 39 | empty |
| 2 | 203 | 0.51 | 0.77 | 27 | empty |
| 3 | 86 | 0.41 | 0.78 | 19 | empty |
Interfaces
1 interface between chains.
- A–D · 639 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 7UL5 · CryoEM Structure of Inactive SSTR2 bound to Nb6 · the same entry in another collection · chain A against A, TM-score 1.00
- P30874 · AlphaFold monomer V2.0 prediction for somatostatin receptor type 2 (P30874) · a predicted model of the same protein · chain A against A, TM-score 0.97
- P41145 · AlphaFold monomer V2.0 prediction for kappa-type opioid receptor (P41145) · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P30874
- Every structure of UniProt P41145
- Elsewhere: RCSB PDB 7UL5 · PDBe 7UL5 · UniProt P30874 · UniProt P41145
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