UniProt P30874
Somatostatin receptor type 2 (P30874)
Somatostatin receptor type 2 (UniProt P30874): 19 experimental structures on GenesisL1, 5 ligands bound, 19 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P30874
- Protein
- Somatostatin receptor type 2
- Experimental structures
- 19
- Predicted models
- 0
- Ligands
- 5
- Pockets
- 19 · 4 records with a druggable one
Structures
19 records of P30874 in the MolNFT archive: 19 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7T10 | Cryoem structure of somatostatin receptor 2 in complex with somatostatin-14 and GI3 | electron microscopy | R | — | — |
| 7T11 | Cryoem structure of somatostatin receptor 2 in complex with octreotide and GI3. | electron microscopy | R | — | — |
| 7UL5 | CryoEM Structure of Inactive SSTR2 bound to Nb6 | electron microscopy | A | — | — |
| 7UL5 | Cryoem structure of inactive SSTR2 bound to NB6 | electron microscopy | A | — | — |
| 7WIC | Cryo-EM structure of the ss-14-bound human SSTR2-GI1 complex | electron microscopy | R | — | — |
| 7WIG | Cryo-EM structure of the L-054,264-bound human SSTR2-Gi1 complex | electron microscopy | R | 9FI | 2 (best 0.77) |
| 7WIG | Cryo-EM structure of the L-054,264-bound human SSTR2-GI1 complex | electron microscopy | R | 9FI | — |
| 7WJ5 | Cryo-EM structure of human somatostatin receptor 2 complex with its agonist somatostatin delineates… | electron microscopy | R | — | 5 (best 0.75) |
| 7WJ5 | Cryo-EM structure of human somatostatin receptor 2 complex with its agonist somatostatin delineates… | electron microscopy | R | — | — |
| 7XAT | Structure of somatostatin receptor 2 bound with SST14. | electron microscopy | A | — | — |
| 7XAU | Structure of somatostatin receptor 2 bound with octreotide. | electron microscopy | A | — | — |
| 7XAV | Structure of somatostatin receptor 2 bound with lanreotide. | electron microscopy | A | — | — |
| 7XMR | Cryoem structure of the somatostatin receptor 2 (SSTR2) in complex with GI1 and its endogeneous… | electron microscopy | R | — | — |
| 7XN9 | Crystal structure of SSTR2 and L-054,522 complex | x-ray diffraction | A | GI9 | — |
| 7XNA | Crystal structure of somatostatin receptor 2 (SSTR2) with peptide antagonist CYN 154806 | x-ray diffraction | A | — | — |
| 7XNA | Crystal structure of somatostatin receptor 2 (SSTR2) with peptide antagonist cyn 154806 | x-ray diffraction | A | ACE, NH2 | — |
| 7Y26 | Cryo-EM structure of the octreotide-bound SSTR2-miniGq-scFv16 complex | electron microscopy | E | — | 5 (best 0.76) |
| 7YAE | Octreotide-bound SSTR2-Gi complex | electron microscopy | E | CLR | 7 (best 0.69) |
| P30874 | AlphaFold monomer V2.0 prediction for somatostatin receptor type 2 (P30874) | — | — | — |
Ligands
- 9FI · ~{N}-[(2~{R})-1-[[(1~{R},3~{S})-3-(aminomethyl) cyclohexyl]methylamino]-3-(1~{H}-indol-3-yl)-1-oxidanylidene-propan-2-yl]spiro[indene-1,4'-piperidine]-1'-carboxamide · in 2 records
- ACE · Acetyl group · in 1 record
- CLR · Cholesterol · in 1 record
- GI9 · Tert-butyl (2S)-6-azanyl-2-[[(2R,3S)-3-(1H-indol-3-yl)-2-[[4-(2-oxidanylidene-3H-benzimidazol-1-yl)piperidin-1-yl]carbonylamino]butanoyl]amino]hexanoate · in 1 record
- NH2 · Amino group · in 1 record
Experiment against prediction
- 7UL5 chain A against the predicted model P41145: TM-score 0.93, RMSD 1.99 Å
- 7UL5 chain A against the predicted model P41145: TM-score 0.93, RMSD 1.99 Å
- 7T10 chain R against the predicted model P41145: TM-score 0.86, RMSD 3.02 Å
- 7XN9 chain A against the predicted model P09850: TM-score 0.39, RMSD 1.07 Å
- 7T11 chain R against the predicted model P41145: TM-score 0.86, RMSD 3.02 Å
- 7XNA chain A against the predicted model P09850: TM-score 0.39, RMSD 1.34 Å
- 7XNA chain A against the predicted model P09850: TM-score 0.39, RMSD 1.34 Å
- 7WJ5 chain R against the predicted model P0ABE7: TM-score 0.27, RMSD 4.68 Å
- 7WJ5 chain R against the predicted model P0ABE7: TM-score 0.27, RMSD 4.68 Å
Elsewhere
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