MolNFT v2 · #168845 · protein

Nanobody-Enabled Monitoring of Kappa Opioid Receptor States

6VI4: “Nanobody-Enabled Monitoring of Kappa Opioid Receptor States”. X-ray diffraction at 3.3, 2 ligands (JDC, CLR). MolNFT v2 #168845 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6VI4
Type: protein
Length: 794 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 3.3
Source: Homo sapiens; Lama glama
UniProt: P41145
Ligands: JDC, CLR

Structure

x-ray diffraction · resolution 3.3 · 4 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	283	—	P41145
B	—	protein	276	—	P41145
C	—	protein	118	—	—
D	—	protein	117	—	—

Ligands and binding sites

JDC · (3R)-7-hydroxy-N-{(2S)-1-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl}-1,2,3, 4-tetrahydroisoquinoline-3-carboxamide · ligand · 2 copies · chains A, B
CLR · Cholesterol · ligand · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6VI4 · Nanobody-enabled monitoring of kappa opioid receptor states · the same entry in another collection · chain A against A, TM-score 1.00
P41145 · AlphaFold monomer V2.0 prediction for kappa-type opioid receptor (P41145) · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P41145
Elsewhere: RCSB PDB 6VI4 · PDBe 6VI4 · UniProt P41145

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