MolNFT v2 · #196778 · protein

CryoEM Structure of Inactive NTSR1 Bound to SR48692 and Nb6

7UL2: “CryoEM Structure of Inactive NTSR1 Bound to SR48692 and Nb6”. Electron microscopy at 2.4, 2 ligands (Q6Q, NA). MolNFT v2 #196778 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7UL2
Type: protein
Length: 347 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.4
Source: Homo sapiens; Lama glama
UniProt: P30989, P41145
Ligands: Q6Q, NA

Structure

electron microscopy · resolution 2.4 · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
R	—	protein	287	—	P30989, P41145
D	—	protein	60	—	—

Ligands and binding sites

Q6Q · 2-[[1-(7-chloranylquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl]carbonylamino]adamantane-2-carboxylic acid · ligand · chains R
NA · Sodium ion · metal · chains R

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7UL2 · Cryoem structure of inactive NTSR1 bound to SR48692 and NB6 · the same entry in another collection · chain D against D, TM-score 1.00
P30989 · AlphaFold monomer V2.0 prediction for neurotensin receptor type 1 (P30989) · a predicted model of the same protein · chain R against A, TM-score 0.89
P41145 · AlphaFold monomer V2.0 prediction for kappa-type opioid receptor (P41145) · a predicted model of the same protein · chain R against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P30989
Every structure of UniProt P41145
Elsewhere: RCSB PDB 7UL2 · PDBe 7UL2 · UniProt P30989 · UniProt P41145

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