MolNFT v1 · #271558 · protein
AlphaFold monomer V2.0 prediction for neurotensin receptor type 1 (P30989)
P30989: “AlphaFold monomer V2.0 prediction for neurotensin receptor type 1 (P30989)”. 5 pockets (best druggability 0.80). MolNFT v1 #271558 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P30989
- Type
- protein
- Length
- 418 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x53c93E7A401667370377170c205e199E26177691
- Molecule
- Neurotensin receptor type 1
- UniProt
- P30989
- Pockets
- 5 · best druggability 0.80
Structure
1 distinct chain · 66% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Neurotensin receptor type 1 | protein | 418 | 66% helix, 2% strand | P30989 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 463 | 0.80 | 0.87 | 53 | empty |
| 2 | 413 | 0.72 | 0.83 | 57 | empty |
| 3 | 50 | 0.66 | 0.96 | 17 | empty |
| 4 | 50 | 0.31 | 0.76 | 11 | empty |
| 5 | 50 | 0.28 | 0.75 | 10 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 6OSA · Human neurotensin receptor 1 (HNTSR1) - GI1 protein complex in non- canonical… · an experimental structure of the same protein · chain A against R, TM-score 0.76
- 6OSA · human Neurotensin Receptor 1 (hNTSR1) - Gi1 Protein Complex in non-canonical conformation… · an experimental structure of the same protein · chain A against R, TM-score 0.76
- 6UP7 · Neurotensin receptor and ARRESTIN2 complex · an experimental structure of the same protein · chain A against R, TM-score 0.74
- 6UP7 · neurotensin receptor and arrestin2 complex · an experimental structure of the same protein · chain A against R, TM-score 0.74
- 6OS9 · human Neurotensin Receptor 1 (hNTSR1) - Gi1 Protein Complex in canonical conformation (C… · an experimental structure of the same protein · chain A against R, TM-score 0.72
- 6OS9 · Human neurotensin receptor 1 (HNTSR1) - GI1 protein complex in canonical conformation (C… · an experimental structure of the same protein · chain A against R, TM-score 0.72
- 6PWC · A complex structure of arrestin-2 bound to neurotensin receptor 1 · an experimental structure of the same protein · chain A against R, TM-score 0.72
- 6PWC · A complex structure of arrestin-2 bound to neurotensin receptor 1 · an experimental structure of the same protein · chain A against R, TM-score 0.72
- 8JPF · Focused refiment structure of NTSR1 in NTSR1-GRK2-Galpha(q) complexes · an experimental structure of the same protein · chain A against R, TM-score 0.70
- 8JPB · cryo-EM structure of NTSR1-GRK2-Galpha(q) complexes 1 · an experimental structure of the same protein · chain A against R, TM-score 0.70
- 8JPC · cryo-EM structure of NTSR1-GRK2-Galpha(q) complexes 2 · an experimental structure of the same protein · chain A against R, TM-score 0.69
- 7UL2 · Cryoem structure of inactive NTSR1 bound to SR48692 and NB6 · an experimental structure of the same protein · chain A against R, TM-score 0.63
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P30989
- Elsewhere: UniProt P30989 · AlphaFold DB P30989
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