MolNFT v1 · #159530 · protein
Human neurotensin receptor 1 (HNTSR1) - GI1 protein complex in non- canonical conformation (nc state)
6OSA · Neurotensin receptor type 1: “Human neurotensin receptor 1 (HNTSR1) - GI1 protein complex in non- canonical conformation (nc state)”. Electron microscopy, 7 pockets (best druggability 0.84). MolNFT v1 #159530 on GenesisL1: 3D…
- PDB
- 6OSA
- Type
- protein
- Length
- 937 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Neurotensin receptor type 1; JMV449; Guanine nucleotide-binding protein G(I) subunit…
- UniProt
- P30989, P63096, P62873, P59768
- Pockets
- 7 · best druggability 0.84
Structure
electron microscopy · 5 distinct chains · 44% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| R | Neurotensin receptor type 1 | protein | 321 | 78% helix, 3% strand | P30989 |
| L | JMV449 | protein | 6 | 0% helix, 0% strand | — |
| A | Guanine nucleotide-binding protein G(I) subunit alpha-1 | protein | 218 | 49% helix, 17% strand | P63096 |
| B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | protein | 338 | 8% helix, 47% strand | P62873 |
| C | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | protein | 54 | 54% helix, 0% strand | P59768 |
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1118 | 0.84 | 0.85 | 95 | empty |
| 2 | 731 | 0.82 | 0.85 | 62 | empty |
| 3 | 90 | 0.46 | 0.81 | 21 | empty |
| 4 | 162 | 0.44 | 0.75 | 23 | empty |
| 5 | 76 | 0.37 | 0.77 | 14 | empty |
Interfaces
5 interfaces between chains.
- B–C · 2164 Ų buried · 13 hydrogen bonds · protein-protein
- R–A · 1317 Ų buried · 4 hydrogen bonds · protein-protein
- A–B · 1261 Ų buried · 16 hydrogen bonds · protein-protein
- R–L · 806 Ų buried · 8 hydrogen bonds · protein-protein
- R–B · 223 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 6OSA · human Neurotensin Receptor 1 (hNTSR1) - Gi1 Protein Complex in non-canonical conformation… · the same entry in another collection · chain C against C, TM-score 1.00
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
- P30989 · AlphaFold monomer V2.0 prediction for neurotensin receptor type 1 (P30989) · a predicted model of the same protein · chain R against A, TM-score 0.98
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain C against A, TM-score 0.94
- P63096 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.83
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P30989
- Every structure of UniProt P63096
- Every structure of UniProt P62873
- Every structure of UniProt P59768
- Elsewhere: RCSB PDB 6OSA · PDBe 6OSA · UniProt P30989 · UniProt P63096 · UniProt P62873 · UniProt P59768
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