UniProt P30989
Neurotensin receptor type 1 (P30989)
Neurotensin receptor type 1 (UniProt P30989): 14 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 33 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P30989
- Protein
- Neurotensin receptor type 1
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 33 · 7 records with a druggable one
Structures
15 records of P30989 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2LYW | Intermolecular interactions between neurotensin and the third extracellular loop of human… | solution nmr | A | — | — |
| 2LYW | Intermolecular interactions between neurotensin and the third extracellular loop of human… | solution nmr | A | — | — |
| 6OS9 | human Neurotensin Receptor 1 (hNTSR1) - Gi1 Protein Complex in canonical conformation (C state) | electron microscopy | R | — | 2 (best 0.80) |
| 6OS9 | Human neurotensin receptor 1 (HNTSR1) - GI1 protein complex in canonical conformation (C state) | electron microscopy | R | — | — |
| 6OSA | human Neurotensin Receptor 1 (hNTSR1) - Gi1 Protein Complex in non-canonical conformation (NC state) | electron microscopy | R | — | 5 (best 0.84) |
| 6OSA | Human neurotensin receptor 1 (HNTSR1) - GI1 protein complex in non- canonical conformation (nc… | electron microscopy | R | — | — |
| 6PWC | A complex structure of arrestin-2 bound to neurotensin receptor 1 | electron microscopy | R | — | 8 (best 0.77) |
| 6PWC | A complex structure of arrestin-2 bound to neurotensin receptor 1 | electron microscopy | R | — | — |
| 6UP7 | neurotensin receptor and arrestin2 complex | electron microscopy | R | PIO | 4 (best 0.82) |
| 6UP7 | Neurotensin receptor and ARRESTIN2 complex | electron microscopy | R | PIO | — |
| 7UL2 | CryoEM Structure of Inactive NTSR1 Bound to SR48692 and Nb6 | electron microscopy | R | Q6Q, NA | — |
| 7UL2 | Cryoem structure of inactive NTSR1 bound to SR48692 and NB6 | electron microscopy | R | Q6Q, NA | — |
| 8JPC | cryo-EM structure of NTSR1-GRK2-Galpha(q) complexes 2 | electron microscopy | R | SRW | 5 (best 0.81) |
| 8JPF | Focused refiment structure of NTSR1 in NTSR1-GRK2-Galpha(q) complexes | electron microscopy | R | SRW | 4 (best 0.72) |
| P30989 | AlphaFold monomer V2.0 prediction for neurotensin receptor type 1 (P30989) | predicted | A | — | 5 (best 0.80) |
Ligands
- NA · Sodium ion · in 2 records
- PIO · [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2, 3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate · in 2 records
- Q6Q · 2-[[1-(7-chloranylquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl]carbonylamino]adamantane-2-carboxylic acid · in 2 records
- SRW · 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol · in 2 records
Experiment against prediction
- 6OS9 chain R against the predicted model P30989: TM-score 0.99, RMSD 0.81 Å
- 6OS9 chain R against the predicted model P30989: TM-score 0.99, RMSD 0.81 Å
- 6OSA chain R against the predicted model P30989: TM-score 0.98, RMSD 0.89 Å
- 6OSA chain R against the predicted model P30989: TM-score 0.98, RMSD 0.89 Å
- 8JPF chain R against the predicted model P30989: TM-score 0.98, RMSD 0.90 Å
- 8JPC chain R against the predicted model P30989: TM-score 0.96, RMSD 1.31 Å
- 6UP7 chain R against the predicted model P30989: TM-score 0.96, RMSD 1.60 Å
- 6UP7 chain R against the predicted model P30989: TM-score 0.96, RMSD 1.60 Å
- 6PWC chain R against the predicted model P30989: TM-score 0.92, RMSD 1.51 Å
- 6PWC chain R against the predicted model P30989: TM-score 0.92, RMSD 1.51 Å
Elsewhere
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